ID G7Y362_CLOSI Unreviewed; 788 AA.
AC G7Y362;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=E3 ubiquitin-protein ligase RNF139 {ECO:0000313|EMBL:GAA47399.1};
GN ORFNames=CLF_100311 {ECO:0000313|EMBL:GAA47399.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47399.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA47399.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA47399.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DF142837; GAA47399.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y362; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025754; TRC8_N_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR22763:SF195; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13705; TRC8_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 722..762
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 788 AA; 88729 MW; 6D974AC9032BAF63 CRC64;
MLTELLSVGD TIIRVPFWFL FELIISSRID GLSKFIMRQP KFVASLCPDC PGVIEERHIP
IFITYIAILC LTAMLFHSMA VFAVHALLLG TTIAWTCLMS YVLLLRFAYA PWEQIDMDSI
TEIYLGSSFS LSLIILCLMS ILAYPNQVTN KRWFLVSSLA AAVPVVCYLP APYLIKTGPL
NYDCHLSQTN GSSAGCSSPA WYAYGVVSLR PRHCHSRELP YDLCILIDPS YGPLFSGSVC
PALSALRCSN YFCDPRVREF VYTLARFSVP VLNILLLLLC VKLTQVVSRL RSAITEQLEL
YRMVGIFEFI SHHWNRLNIP RTLAFLWVFK VFAVILYGPK QWPIFPTGYK ETDAHFSNLS
LLRRYGAVEE QNQTTISILL TRASVGALVH GSESWLIVFG AASFFGAMAI LVVNTLVRLL
DPRGKHLERL FITAREAPVD LLEWSVIEDP ALAMDQNDLL AVEMLSGTGW NSAVVFLFLA
FQYDLPSLPV SQRVSCCLYG ITVIAITCVH PVQALIKSLL LRLDAPGRRD SSTWFDHLRP
LVFCFGLIGA SFCIINYAPE QLVAANATPA SAASSTSSAP LLPRFGSSVE SLKARQMRIV
LCGCQLLLGL IVTLIEYVIY QISHRIPDWS GFRPALFWTK LISSVLDYMI SLLSFLTVCW
LSVYDSIGVC RMFIICCYFY FILYPSAVRA YTWVRWKLLF RQRIHSLASP SESELVNRGS
TCPICYVDMT PDSSRMTRCG HLYHIECLSR WMRRQLFCPI CHADLLSTKV TDRRRVTGNQ
GNIQPAQA
//
