ID G7Y4B9_CLOSI Unreviewed; 1001 AA.
AC G7Y4B9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Paladin {ECO:0000256|ARBA:ARBA00040012};
GN ORFNames=CLF_100823 {ECO:0000313|EMBL:GAA47805.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47805.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA47805.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA47805.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the paladin family.
CC {ECO:0000256|ARBA:ARBA00037958}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DF142854; GAA47805.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y4B9; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 3.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR23339:SF96; PALADIN; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF14566; PTPlike_phytase; 2.
DR SMART; SM01301; PTPlike_phytase; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 115784 MW; FDA0D6B9C23097A5 CRC64;
MGTVASFGPC PSKKGTRRKK HSGRIHEAHS APELTQAQVA EGTPDAASLN DVNNPQEQKK
NKRAAVLLNN FHEEYQILAD EMPNIVYARV VPNLPEHPMI HGRYCFVRDT ESEQDHLSSS
GDNQTVASVY MDRSKTNLPI VGISQTSVKK LRQVVRSCIS RLPMWIILNV RNDPCLFSIV
DDDWLPYTLR DYKAIQRVLA DPHCTGKDMD EMEFQAREEV LQDVKALREQ EFFFYDDITF
FENQPQKHLT CQPDHLLLSE EVYVSIALAS TNVWYLRLNF PKMGFPLEEE VDRFVGVFNE
LCNNTLPRNP FSKTSAENLR EINRLFGFLV SGRKLHDETV QLGMTMAYLA LRQLHSLIVS
SVTDSPLTGM FDQKSIPAPK DAAAASKSSE QNGLTLGRYG NFKKSSECQM LTAQHQRVKA
GKFQFVRQVG RYLPFMVQIK EEVDKAIDDC DTIINLREEI LETLLELESM NFSFDMDKKL
AHIERRNELV HQMERYYMLI CFNAYLRDQL SDSSLLIDEL CTKRTTGLAN FRQLVGWPIY
GTSQPDATTI KRVHLMITTA YWNVALNGRR MEETVASPLK HQPNRVPISM PNMIWICLRD
GYAIAHDGEV YTWRLKDDPE EAIVLKGISG AEMEEFEEKF VESIKKVKTP IKLHEFDMDN
NKISEKIPLN AEKLHTTKQL FKESFEQNAR DDTLNNQDSA MPNIPESYFN YVKKHAEYHR
IPIPMYGFPL PAMFDQILRI VVNNARGLFT SAITAQSLVN ASAGMGRRHV TIRRPSAANI
GQTDWSLPNA NEAKIDRIAS TNLIFFCENG RERTSLAMTI AGLVYCHLFG FAFGYRVEEE
ERVSLRGAKY TKGEFQVIQT LIRRIPNGNQ VKREVDYVLD RCFDSMSMMH FHIREEIYFT
YAKFRDEHDP VKKEKLKHRS LAYLEEYFFL ILFNLYLHDC QSSHWKNPFD VWMEKITERC
NYMELLNELG FPEFETPDHL RRLRERWRPR IDAKSSFMGI V
//
