ID   G7Y7X9_CLOSI            Unreviewed;      1267 AA.
AC   G7Y7X9;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=DNA excision repair protein ERCC-6 {ECO:0000313|EMBL:GAA49064.1};
GN   ORFNames=CLF_102439 {ECO:0000313|EMBL:GAA49064.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA49064.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA49064.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA49064.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF142928; GAA49064.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7Y7X9; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   CDD; cd18000; DEXHc_ERCC6; 1.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR049730; SNF2/RAD54-like_C.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR   PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          161..350
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          511..675
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          45..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          739..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        922..948
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1267 AA;  142679 MW;  3D992A5BEE319906 CRC64;
     MKQIDVLNSR KQSLLSKLSM LQDTSLSDQP NLLAYSQTTE SSMASLTTAA PVSKPTLPEH
     KRKDPPTIVR CTKSPPVKKI RLPKKPIRTI KKLDDANLEQ FQKRLRRQRH LDALERQLAK
     EHGEDPDPVP PDGQLDKNFL VPGRIWSRLF EYQRTGVNWL WQLHQKQSGG ILGDEMGLGK
     TIQIIAFLAG LHYSEFLVTG KSGHLGPGPS HRHSTGDFAS ALIVCPATVL QQWLREFHQW
     YPAMRVAILH STGSGYQKPN SLIRSMGNHP GSVLLTTYQT LVTYQDVLTA VEPSWTYLIL
     DEGHKIKNPE AEVTHAVKRF ATSHRLILSG SPMQNNLREL WSLFDFVSPG RLGPLPEFMQ
     QFAIPITQGG YASASPLQVE TAYRCACTLR DLLMPFLIRR LKTDVQIQLP AKSEQVLFCR
     LTNYQRQLYR EFAESQLCKD LLNGKGNVFT ALILLRKLCN HPDLVTGGPR DHILLGDELP
     EDDVDVTTVS RISEYGWTRF GCPRRSSKML VVASLLRTWS TQGHKVLLFS QSRRMLCLLE
     RLLITLGITY LRMDGSTPVS QRPALIDRFN RSTDSSAENI FVFLLTTRVG GLGINLTAAN
     RVLIFDPDWN PMTDLQARER AWRIGQTQDV IIYRLLTSGT IEEKIYHRQI FKQFLTNRVL
     KNPRQQRFFK TNDLQELLSF DDGESASRKK DQAPETAKYV HCEGLGHTVL DASKSVIGNP
     KIVNRFDLLQ AQGKVIVKET TEDETDSDDS HEEEIATTTA DAQQTSAQPL RADEARKAQL
     RQLARELSKR IGEGRLNEDK PLKLRSKLRL KHPQRRGTRV DGKRIPLISR RAVYDCGDVD
     TTPSPGHSKD SRCEKLLPIA DETSKDVFLT TLLVAPDGVA SAELQSSMKV KRSILDEELR
     AEAERVATEA LIHIQRYSSS KTCKDLTSTT EPGTSCSMPT SSKHTAPMDS DSCGIFHAKR
     DKNDKPTSSD NVQASEQSRK RKVVHSASRP KNSTPHLSHV SHVLLHDQLI DDFTQESRID
     HSFYTSEARH LAEVIAEELL REAQTSFDPQ APEANLPTSV LSTVRPFGLV HNRFLWNPSE
     HQSPALAYLS HSLRQNALSS QNTGIKSFDP RQQSPLDASA VLVGHVRFSS SILLQLISVR
     HTARQSFPAT THREPSHARG SIQHQMQVLC CELIRILTGS SLTVTSGFLA SCFNHILCKD
     SDSVNDLNAL HFRAILRRVA GRRRAKDSST DASSRCRYND VWFLRERYRD IAQYLSNQLA
     SCERSST
//