ID   G7Y8S4_CLOSI            Unreviewed;       423 AA.
AC   G7Y8S4;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   28-JUN-2023, entry version 35.
DE   RecName: Full=NAD(+) kinase {ECO:0000256|ARBA:ARBA00012120};
DE            EC=2.7.1.23 {ECO:0000256|ARBA:ARBA00012120};
GN   ORFNames=CLF_102921 {ECO:0000313|EMBL:GAA49359.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA49359.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA49359.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA49359.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
CC       {ECO:0000256|ARBA:ARBA00010995}.
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DR   EMBL; DF142952; GAA49359.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7Y8S4; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019674; P:NAD metabolic process; IEA:InterPro.
DR   GO; GO:0006741; P:NADP biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   HAMAP; MF_00361; NAD_kinase; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002504; NADK.
DR   PANTHER; PTHR20275; NAD KINASE; 1.
DR   PANTHER; PTHR20275:SF0; NAD KINASE; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
DR   Pfam; PF20143; NAD_kinase_C; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:GAA49359.1};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          228..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  45785 MW;  D8A7FC983A5D4568 CRC64;
     MIRRSEPSLY GSYKPCTIGT LIPAATVSIT GKRECGTYNE ALEAKPDDLH RKCHSLSRRS
     SGRLSGVTDC SDLPHSVAFR TWDVTLFLES ETVAVLKKDA HFSSVLGRTT GPQATSSTDH
     LPAGLSDPVP CILNPNDTQN KNLSVKIYDC QNANSVDLVI CLGGDGTFLK IGSMFQQAVP
     PVLAFRLGTL GFLTPFPFGS FQSCIRRAME GPSTCLLRTR LRCEISRGDQ NGKSVTDDSD
     TSSSRSNSPD KEYHFLNELV VDRGLSPCPC NLLVKVNGKP VTHFEGDGLI VSTPTGSTAY
     SMATGASLLH PCVPAFLLTP INSLTLSSRA IVLPMTVRLE ICINSTARCK LAHFSFDGRS
     RASNLIRDGD SISVTGSPYP IPCLSTEDQA ADWFCGLNSL LNWNARRRQS LHWSGSLCAD
     EDT
//