ID G7YD77_CLOSI Unreviewed; 3115 AA.
AC G7YD77;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 39.
DE SubName: Full=Microtubule-actin cross-linking factor 1 {ECO:0000313|EMBL:GAA50911.1};
GN ORFNames=CLF_105215 {ECO:0000313|EMBL:GAA50911.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA50911.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA50911.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA50911.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DF143092; GAA50911.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR Pfam; PF02187; GAS2; 1.
DR SMART; SM00243; GAS2; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 2897..2932
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2935..3008
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 659..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2136..2158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3005..3115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 915..981
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 666..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3015..3073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3082..3115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3115 AA; 351602 MW; 5742518EB153A2D8 CRC64;
MIGLSKSLEN ESEMRLFGAN ADTHEKLQNE YWECYVDLHR FIQSTTSSVA TLLRKVQRYK
QTELQALKFK LTDTLQQVQS LMQKLLEIQR TVTRFDREYC SLDLFLSSTF RRQRWLITPR
PVQNKPMVNG SPHREEESTS CGTLVDALDL TGNGKRKRIS PRKINYGLDA TADSLNKRYS
APFGCAEVQQ ALASRFVHFQ SDLRRHLYVA WNLLSGFAWL AVASTLIRCK FRKGMLHKHH
LNETNPSETL LFENLIEYMT SEPVQVLARQ LTMWRLVQDP CPAKRSRTED GMTHQLQMIF
TRLRTMNWTG KDAPPDDMAG MCHVLFEIQN LFHDIQTHRQ HYTNISLVDG SWQLGHTNIM
TSSNAVTLKV FVRQVNAHCI ALTGAGAPLK PGYKRSQIVL YCSQPSVSVW PSISSTNCCS
KTQNSTLAIE ERVYERRIPI CGQKQQQASG SVNNKDNAAA CTHEFDTENG DVHFEEVNSK
TADRVVSRFV CPSTFAKCTQ VSISVRPNLS SYDYHKTSNN SITSSYTSEI IVFLTASHKT
HIGKQTRQDI SASPDDCSRS QVSLVNHSEL NEPWASPLLH DSVMSDYLGV LSPLPVPEQF
ANVESIEWNI QGKVTEQEQC SSSICEDADV QSSVLQTDCV ECTTVSRDLE SSRLSVLDPI
PECDSQANSD AKSSARGSEM TNSEHPTTET DGHLFDGLVT TTIEGQMNDL LVQTEELEQT
VEWVAAQLCK IDGYTTRDLM VDSTRIPLHL AFIDQANEAL TPLGGRIRQM LRQINQIEQS
PVCGVQTEET ALVQNRVKQN AVDLTVLSEF RTRLKRIRKE RSVKLHECEQ LIIQLQQAQT
LQGDISANLH SIQAELARCS KLIDNHEDAP TRICWSPDHG LKDQLDRFHR IATDLTERVA
PHLAQLSKST KEFQFDRLDD QISDATAELE ELICIVCQKK ESLERLDRYL DRLNLRAKDK
LASLQNELTN VKRISLKAND QMTPEYLAIL TKDLYNKCTR LQDLQSELHP VLTDLFEVTQ
TADSNKILLQ YHVEGNLEGV DCFVQLKMDI TNFWTQLTDE LEEQMKHLMD SVSEMVTISS
EAGTFGPTGQ TKTLLHSGEL LKPEQLQLQL ATIDQQISEL NSHSDWIKQN LDPLLYDKSF
TLLLDDDKLT KRDELLSRLD EANTQLHILR DELQTVYSPA VMALNERIQK AQSFLKLLYL
QSQELPEPLV KFEELDVSVS ELSIASQLEL LHVQRSQCQQ LLQAVQNEQH CFTEDITHIW
QANGLGSEQL NILTEISVAG TQSAVDDETP ELVLGSVMGM GPGVTLKCLL QAYTHLGQKV
ANRIDQFHSD INELSQKRCP MDESESIASV DETDAQVTYF EVSESDSGLP GELSLTLVDT
MAQLTLLDGV NETYNHLDID EVESELQDLV GGVDVSADVE LSSTGILPEG TGAKSEKETV
GAAGDTTVDK EVCWTSTLSQ PASQWFHSEE VQLRQSEAKL NELKLRYHQV VHSTLTSLKE
SDYSSIARLS EYFRTTLTLI KEISTELSLL TRIEGSNYPM TSPLVGDDET VNENIIQLTL
KSNAIPLWYR IEGLEIHTKY FVDAVSECEN LILTAYELSE RVSSMTTRLG PWLEDQSRIL
GEVNQVDPCS STTDELLSLL NTLSTTKLMI RSKAGAIGQV IHDVNNLRQT LAQFNAKINF
ERHLISWDAH RQDHWTPPTI EANSDALNLP LYTHLDRLDA VYTNLVKMCA DSTRTVCTRL
FDIGRADLVL REIEQTVNDC GVSALESHPN DEKESSNAAV QTITTDSSAV AGCFSGIVRR
KQLEVYVSEL TTYLTLMDQF ASAQKQGQLP VVCDTSLNPM WQRVYNRLLI NLNTSSNSLL
KSKCEFAQIR KIDSFMYNSA TWLRRNGFRL FRWTDPKGLS LETASAKAND FREVYTKIEK
ESQAKSAQMM DNIRESIMLP ISSDPMIKKF VTYLEVVLLG NNSSNDQPEA LDDLSAPGLR
LFVHEQHRYK RFVSFLQMAW DCHIKFVAHY EEKIHKMSTA FQSLHATLAK LYRPSKLVAQ
CSEQLMEVED AISLLQEHAT IVGGMYSAVP QLRCLCQPSE VSKMLATIRS MKHEFLCLSS
RAEERKKILQ QALKEDVVFD TAYKRLMSTL KNYCEENSSN PPANSTVKNA KASEPQPSWD
LQRESANYWA VLRLGCYLRD RCTQSDPERG IIDNMLTDLR HLWYACFRKQ AERSLACEKA
LLDRGAHSAA CEKLNEWIRT FESTLKISTS VSEILSVSNA DTLGPDIIKL MSFKWCTTSK
TTNIQLVFIK DDSRLRECGF SSSDLQSLVS VYGDTALVHS IQDEVRLLSE ELDRRMHLWN
VDEPAPISDD SRRNVPLHLR IRMMRLRVAL ELRSQVLESA MDVATAIQQA WLTLSNWLCE
LEARIKRTRC QPNSINSSMH RTASFTQSQL DTYEYAQFTR THVTAPILSC YSSVMKHLLT
MNETEKSSAD TWIMGRCHSR TKAAMRRQFQ SLISKWKQMD QLLKVLQMSL RQSGCVPQCV
WDFETLECTI EKMTKDTKRE RGRDQLLSKK LTEALLQPDD GKLPNNGSED GPEPNKLCQL
LCDPLVKWDT DNPLTIECYL NQCEAQLINA TAMKNQVNSL NSHLRVTLSA YKKMFITVES
CETSDNTSRL YDHSANTVVD SQATVDEPDT ISNSWSQDST RRDSALVLSS LRDSSTELKL
DSHTDGDNTD QLGAMLVLRR GRCRKLEEDF SQLKQLTLSR TENSRVLREA LCERIKLDQF
DFETWRKNFL KWQTKRHFRV SDLFKAVLPV DTSSSQRSTG TTFSTDGSLC SEDDERCTND
CSTSSDIAIT SPPLTDKTSV SPNKSVAFGS GKQRLKSATS LEHLGVVDKQ EPSLNIELTC
SQFVQGLHRH RPDFRGSDCV SLRAAFAEID KNRRGLITIK QLMDALQPER QRQEIPVSQL
IQNAIDAETK KCRCKTKFVP VKVDENRYRF GPSSQLYLVR FLNSITMVRV GGGWQNLTEF
LATRDPCRAR NKPPPSESPS VSSMGTHQVS PAQSVALSRS SPNSNLGSMR VTTVSRTSAE
SIGSPNRTPA KLTARGTPKQ APKAAPTTTK RVQGKNTKSA AKSNLKDGLE NGNSH
//