ID G7YLV4_CLOSI Unreviewed; 1515 AA.
AC G7YLV4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Intersectin-1 {ECO:0000313|EMBL:GAA53935.1};
GN ORFNames=CLF_111669 {ECO:0000313|EMBL:GAA53935.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA53935.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA53935.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA53935.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; DF143654; GAA53935.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0098588; C:bounding membrane of organelle; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR CDD; cd00052; EH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 1.
DR CDD; cd11839; SH3_Intersectin_4; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR012493; Renin_rcpt.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF07850; Renin_r; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00027; EH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1474..1494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..192
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 136..171
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 533..596
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 651..711
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 762..826
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 908..969
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1023..1217
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 30..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 230..426
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 41..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 169140 MW; 478731450B18528C CRC64;
MDADGKLDKK EFSIAMFLIK KKLEGMQLPP TLPTGLKNDP QPVFIPSSSP SLSRSSVLDT
PVGLPSNKSS LNGLAPPLSP VPTDSTIGSD VNEPHSWTIG PNSRPKYRLL FNQHDRAKRG
FITGVEARGV FLQSGLSQQI LAHIWSLADL DKDGNLNCDE FCIAAFLIDK ALAGVQLPAT
LPSGLYPPQL RAGRQTPSNL QPAQPASEDE GKVPALSFED KRRENFLQGQ VELDRRKQEL
AEQLRQEEEA RLEKERQEQE RLEKLRQVKC FLILEKEREK ALETERQAER LRELEAQREV
RRRQAVEART KAWRAAEAQR QLEAEKQRVE ALQKEKCQAS TLLEQAIAHR ASLIESASSQ
EQRKRELETR LFVASAEVDA HKCAINDMRG KRDTYERDIR ELTEQVEAAK AELSRWQRER
EQLSLRVSTG VDTNPTAEQC KTLRASSDLR RASIQRLESQ LAELDEGMTR QGEQLASRRN
TVTELEKRSC QLDVELARLR QKLEGQFRSY LTLKNPGNVE KLFDGLGSLE TGDQIEQYEV
MFDFTARHPD ELSLSTGSLV QIVSEPPFPV AAGWLYGESN GMKGLFPESY VRKRVTGKID
PFDPFGVHKA TTNSTQKAVP SSAFSDFALS KQTTTPEDNK RAKSDPPTSS GPLFSCIALF
PFESTVPGDL NLAVNDVVHV YAIRDEWWEG ECEQTKLSGL FPANYTKKLT PEPNPTPPIN
TTIATTTSSQ SDTELTVSAT KSESPAPGSG QASPSSHITI TTKPEFARVI APYTATAVGQ
LSLQPGQVVQ LRKRSAKGWW EGELQQRGRV RQFGWFPADY VKVISASSLN GSQTVPGPLK
AAARSTTDSC SSITAMVSTS EAPTGTTITH TTTSPKMPTT EPSISAISTV PSQLAQPTQP
TQTTIVNRPV EMMQAIFSYR AAHADELTFE EGSVITVLGR DEPEWWRGRL QSSGAEGLFP
VNYVRPYTQP VPGAPSKQPV PHGPTTTGTV SFSAFVSTAN TKHATESYTV ESTAKLDGSR
EHKRNLAIFE LLQTEETYAS DLLKLQTDFC EPIRRIGLLT EDELTKIFSN FVELHQLSLE
FHRALQQQVD MAGSPEVNNS PIPIGKVFLQ QTWNWFLHIQ LPKFSAFRHY CKYQESAIQT
LQQLLIVVPQ LKMVLLQCEH GNLPLSSYLL KPIQRLTRYG LFLQRILADT APFHPDYEST
LQANERLTRV LNSINTTVGS HTRKNHIRWL QNHLLGESVS LSWLLTPHRP KMLHYGTLYK
PKSNRELVAF LFDSHLLLAV PNPPLLGRSF EFPSVFFGSN VTLKVYRQPI ALGEVVVSAG
TSLSNVQVDK LFRSLSVLSP TESNPTDLHG RLRSSQSSLD VASPSIHLVR APSFLTPLQP
VFSLFSRNNP NEPLIRLKTR AVEERPILAP QFIVILSLSC VSEINGFHTF GRPFKSAPGI
HRFRRHHRAL DPTVITELNL APDVGDEYPV LFQIMLWTSV ALILIIWGVS WGIWNMDPGH
DGIIYRGTAV RPKRD
//
