ID G7YM27_CLOSI Unreviewed; 4196 AA.
AC G7YM27;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 08-NOV-2023, entry version 49.
DE SubName: Full=Dynein beta chain ciliary {ECO:0000313|EMBL:GAA54008.1};
DE Flags: Fragment;
GN ORFNames=CLF_111891 {ECO:0000313|EMBL:GAA54008.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54008.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA54008.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA54008.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; DF143683; GAA54008.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 1912..2048
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2526..2671
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 791..818
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3342..3393
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3654..3737
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 4196
FT /evidence="ECO:0000313|EMBL:GAA54008.1"
SQ SEQUENCE 4196 AA; 479749 MW; A9949C2719519CF2 CRC64;
MSVEDIEDLR LRFVFSYIQL ITDVKYDKIK KFLDDSKQAE KLLDFFEHSD LTHLFVVLHP
TGIFEIHTKF PEVFKFKAFY FIKKERGVIE KNTDWHALNA LLSYGDMDKS PLHHFIAFVN
TVLSPIILNE KNREDWPESL SEYIKRDLYN LQKKSAMVLA RIEGKTHLAH PVGIEKIDTQ
EPISCHGDDV IGSLMYAIET AVVDWSAQIN DILKQQSGQA IANGEFPLPN FEYEFWQQRM
NCMQDIYEQL VHPKVKKMAV ILEANKSAYA NPFKEMFKRV VRAIVESETI VTFLTPLINY
LNDLETVQFE ELKPKIQPIV HLMALLWVNC EYYRSTDRIV ILMTETCNLL IQLCRQYLDP
TEIIKEEPDE GLIKINKSLD ILRHFRDVVE DYRQNVKESC QEQNVEPSEW TFHSSWVFSR
LNAFIERLES IRVYYHTLLD YNRLEKVEVH GVVGQTLTTR VSMVYDEYQE AYRKFTDTNM
DCLSTEDTTF STALSEFMKL FDHWDNRMST IIVKAFLLSN TTLGAFKTIF MFGPLLERTL
IKPIFEPCYA ELLSKLHLEL DTCKEILDSH FDQPERLNQT ISKSLPPAAG AIAWSAYLLR
RVLSVMGPID LLDYPLLQTD QGERLLQKRD ELLELLSTFR AQRLEEFCKT APEKCNVNLK
LPLLRRNPAM QTIEVNFDDQ LVEVLREVHY LLFLSGEDEC ALTSPESVVF GLPEKIKDSL
PASTLDMYKR LEPLRESRLK LAQIQNAYNS VRQKTLTVEF PLIADEVDQF DDLLGPALKT
MTWESVDSGF IDTALETVSE IQSRVTKAQE NLKQVEHLSG QWRALPLYQG KERKYDCLIP
LDEREGLRET RFKEIASAAQ KIHELIKENL ELYKAEEDGP DWSAYLEAAE DIILEGLIEA
VRCSLSYLAN HTEKGKVESP LMETKLNLVD NRLSYTPGVL ENQAENLLDL VDSLVQDITD
QSRLIPSLTN QPQAPPPSAS QVAAAAEPEA VDVSDVSVEQ TEPSSEVSLS QQVKSLVGFS
LQVLNTPEIS ESIKKITDHV RSAMRSATDF QSNLEASYSV YWAEDRTEFI RQFCRYGRLL
TKEDLGPTGE IEAPENPPTL EQFREQILKY DRVYEEVEHL EDSHVFDTWL RADLKPFKMS
LLAVIRQWSD KFKQYLVDHV TSTLDNLKAF IEDSINDLEL KGDPEKVDYA KLVTVLERLK
LIREAEDATD AGFEPLRETV ALLKEFGEEL PDAMNKLLES LPEQWHELKN IAVLTKQKIQ
PLQEREVQNI RAMSAHYDTE SARLKREFGE SEVFTFDCSE PYESLDEWNT RLTEIEEGVA
EMQVSAKSFE VRDIPTYLDL KAMRREMKVT KRVWDYINMF RSYVTAWKTS KWKEIDFGAI
DEVIREISIE IRTMDKDVKQ WPMFQGLEAE LKDINAAVTA VRDLQNPAVK ERHWVELMTD
TGRMIEINDE TTLADLLSLN LHKFEEEVHG IVSKASNEQK IERDLEKIEQ VWSEMMFEYE
THDRTGLELP KQTEELTGTL EEIQVKVLDM LGNRDNTFSI DRINYWHKTL SMTDQVLTLW
FETQRVWSGL ESIFVLCDDI QAQLPDDTAL FMDLDKEFRV LIDELQSKPK VLDATTQRPE
ILDEIQKIRD GMTICEKALA DYLETKRLSF PRFYFVSQVD VTDIVSNGKV PAKVLRHLSK
LFDSICSLTF EKPDAAVKHA TKMIAKDGEE VKFVKSFDLT GQVEEWLNQL LDEMRHTLRK
ILADAVAAYE EKPRDQWIFD YPAQIALTGS QIGWNSEVQI AFGRLEEGLE NAMKEYNKKQ
INQLGILIQM LLTDLTPGAR QKIMTLCTID VHNRDIVGKL ISQKVDSSQA FTWLSQLRHR
WDDARQDCLA NICDAQFAYA YEYLGNTPRL VITPLTDRCY ITLTQSLHLC MSGAPAGPAG
TGKTETTKDL GRALGVMVYV FNCSEQMDYM SVGNIYKGLA QAGAWGCFDE FNRIAVEVLS
VVAVQVKAIQ DAIRLKKERF NFLGEIIPLD PAVGLFITMN PGYAGRTELP ENLKALFRPC
AMVVPDFELI CEIMLVAQGF LDATILARKF ITLYQLCREL LSKQDHYDWG LRAIKSVLVV
AGALKRGNPE HSEDSVLMRA LRDFNVPKLV TEDMAVFLGL ISDLFPNLDA PRKRNMQFEA
AVKQATEDLG LQPEDSFILK VVQLQELFDV RHSVFIVGNA GTGKSQVWKT LKQTYRIKKQ
KPVAVDLDPK AVTNDELFGI INPSTREWKD GLFSVVMRDL ANMTGPDPKW IVLDGDIDPM
WIESLNTVMD DNKVLTLASN ERIPLTDSMR LLFEISHLKT ATPATVSRAG ILYINPGDLG
WIPYVHSWLD ERVRAKKTLS RTERPALSIC FDKYVGPSLE VVRSKFKRIT PIPDIAHVEM
LCYLLECMLD AQMASKDTRE FTKENYEMLF VFCCVWAFGG SLFKDQLADY RVEFSRWWLN
EFKHVKFPST GGVFDFVWSL QSRKFEPWNS RLTKCELDPE VPLEASLVPT VEVVRLRFFL
DLLIEAGHPV MLVGAAGTGK SVIMQDKFAS LSEDFMVKNI PFNFYTTSMM LQDVLDKSLE
KKAGINYGPP GQKRLIYFID DLNMPEVDQY FTVQPHTLIR QHIDHGHFYD RQKLTLKRVS
KTQYVAAMNP TAGSFTITPR LQRHFSVFAL SFPDESAVKT IYSTVLKQHF VRNSFPATLV
RSVETLVEAC LAAHNKITAV FLPTAVRFHY VFNLRDLTNI FQCLLFSAPE TCNSVLSLIR
LYRHEAMRVY TDKMLDVADT ELAMKHVTNA LTSQFPEVLA ADITAEPLVY CSFSKGLSGE
RAYSAVESVE GISEVVINAL NTYNDNFAVM NLVLFGDAIA HVLRICRILE MPRGSALLIG
IGGSGKQSLS RLAAFISGFE VSQVVLRKGY SQNDLRNHMA QLYLKASLKN MPFVFLMTDA
QVADERFLVY VNDFLASGEI PNLFSDEEME QIIAGIRPEV KSVGLMDSVE NCWQFFIDKT
RKMLRVILCF SPVGDKLRLR ARRFPALVNR TSIDWFHEWP EEALLSVSAR FLEDCPGLSE
EVLPSVSQYM AFAHSTVNEL SRDYLDKERR HNYTTPKSFL EQISLYKRMV GAQIEELQQK
IDRLVNGLDR LRDAGEQTSE LKVQLAAQEV IVNEKTENAN KLIAVVGQET EKVSAEKEIA
AEEEAKVSVI KAEVTRKQRD CEEDLRKAEP ALIAAQEALN TLNKNNLTEL KALTTPPPDV
VLVCSAVMCL FAMDGKLPKD RSWRAAKAGM MSKVDQFLSN LLNYDKEHIH HNSKQAAMEY
VKMPSFDPDV IRTKSSAAAG LCSWVINILK FYDVYLEVKP KRDALDAANE ELRQATEKLE
VLQKKISILE ASLAELTANF REATEEKLRC QQEADFTAKT LDLANRLVSG FASENVRWAQ
QVEVLRELGT TVVGDVLITT TFISYFGYLS KPFRQQLMDA KLWPFMRSLA VPIPIRSGID
PLYMLVDDAV IATWNNQSLP EDRMSVENAT IFTFCERWPL CVDPQLQALK WIKQKYGSDL
IVTRLGVKNY LDQIERAIMD GHTVLIENIG EVVDPILDPV IGRQTIKRGT AIKMGDKEIP
YNPNFRLLLQ TKLANPHYQP ELQAQTTLIN FTVTRDGLED QLLAVVVSKE RPDLEKLKSD
LTKQQNEFKI TLKNLEDSLL AKLASSGGNF LGDHSLVENL ETNKKTAKDI EEKVAEAKIT
EKEINQAREH YRSASSRAAL VYFVMNDLCH IHPMYQFSLK AFRTVFEQSI DTAPEADSDK
ERLISLLDNI TYSIFVYTTR GLFEKDKLIF LILMVLQVQL ASKELSPVLM DFLLRYPVVP
DVKSPVDFLN DLNWGGVQTL VKMSNFRDLD KDIIASAKRW KAFLETEAPE KEKFPQEWKN
KSAAEKLCMM RALRHDRMTY ALRHYVGTTF GSKYVEARQI EFGRSFKESG PAAPIFFILS
PGVDPLKDVE VLGHKLGFTL DQGNFHNISL GQGQEVVAEA ALETAAQEGH WVVLQNIHLV
ARWLSTLEKR LEQYAESAHP DYRVFISAEP AGDPSAHIIP QGILENAIKI TNEPPTGMHA
NLHKALDNFS QETLERCTKE AEFKPILFAL CYFHAVVTER SKFGAQGWNR TYPFNVGDLC
ICLDVLYNYL EANSKVPWED LRYLFGEIMY GGHITDDWDR RLCRTFLEEF LQPDLV
//
