ID G7YN91_CLOSI Unreviewed; 762 AA.
AC G7YN91;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Glutamate receptor ionotropic kainate 4 {ECO:0000313|EMBL:GAA54422.1};
GN ORFNames=CLF_102961 {ECO:0000313|EMBL:GAA54422.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54422.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA54422.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA54422.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DF143892; GAA54422.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YN91; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:GAA54422.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 268..655
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 277..333
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 711..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 84770 MW; E8B9ED9D4FD07270 CRC64;
MTAAPTECPS FELIPNNLEA SNTTVLVGVP SIRFPSAAEV AALSAFGSRL ASARFSDTVF
ATDEYLGPNS LFSDFGALEF VGRYFIKLQS DLSQTDMLAL LEKLHRIVHS QLWSFKVNQP
TMRRVLNSLA IADWTNDLLE TAWMLYDESL NEAVSLTVHL KLMCRCRFFV QLGIVSAYEA
VKTTALALGQ LIMTAQWPES IDDNEVNLCN VSPPKLNVST RYYKFAEAVR KLPSRIGAAG
EIVFNGSVFN HNARVRLMRC DTDGSKSSNR CEDMDPPFVI KTEDGWTGYS VEVFEKIADA
LGLDYVYIEQ LDHIYGVKLP NGHWNGVIGE IASKHADVGL GPIVQDGERK LVVDFTIPYY
VSAGLAMVVS TKTDQELGPF FFLEVFTGPV WICCITAVVF VSLLVYALDR FSPYSFQNQA
LKDNGASEAG TMFTLKESVW YVLGACTQQG ESLDPRSTST RILITGHWIF VVIMVSMFSA
NLSARLTVSG LKEEIKSLEQ LAGQTEVKYT LRSDSAEYAF FRKMYEVEES LFRIWRYLSS
NLTEFSSNYS VWQYPITERY GTIFKRMEEW GFTQDTVDSL AHVRKGWVVF MESSLAAYHI
ASACDLKELG ERIGSWDYGI ALPLKSFLTP NMNSMILHLK AENILDDLEH KWWSTNITGC
PEPSASIGFG LEQVGGMFII LACGFLSAAL ILGMELLFYR VILKRLRKGN KTAPMDDEKP
ADKADARGAQ GGTPPPALVV TPPDCVNVND DSSAPPPYAR NP
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