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Database: UniProt
Entry: G7YSK6_CLOSI
LinkDB: G7YSK6_CLOSI
Original site: G7YSK6_CLOSI 
ID   G7YSK6_CLOSI            Unreviewed;      1049 AA.
AC   G7YSK6;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   28-FEB-2018, entry version 37.
DE   SubName: Full=Potassium voltage-gated channel protein eag {ECO:0000313|EMBL:GAA55936.1};
GN   ORFNames=CLF_109414 {ECO:0000313|EMBL:GAA55936.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea;
OC   Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA55936.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|Proteomes:UP000008909}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L.,
RA   Lv X., Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C.,
RA   Hu X., Xu J., Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C.,
RA   Xu J., Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF144117; GAA55936.1; -; Genomic_DNA.
DR   InParanoid; G7YSK6; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01464; EAGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008909};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    248    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    393    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    467    486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    498    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    164       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      601    701       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      995   1015       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1049 AA;  116518 MW;  132BF98F8614D0C4 CRC64;
     MDKSGNWFIT IRPMGTLTSP SDCLIICMMR SFRAFIVRLD DLKLLVTCFL LANARILEYP
     IVYASSGFAG QMGFSRIEVL QKPVVCTFLQ GPQTSKDGIR CIETALKEQK SEQSELILYR
     KNLNAGWFIV RVIPIRNEQD EVILFLVTFR DVSAFRQPVE EDLVAHSALG AFAVASDPGS
     MQNVIQRPKI PFYSLLSILI IQHTGLNVDA DDYTPSHWLS GDTAPRYRLE PPCPPKHVLL
     HYSAFRVLWD WTILLLTGYT AVVVPLRLAI IPRPTWGRSP HGYASAIKTT RLNVPDSLAI
     ADAVIDIIFC LDIVLNFHTS FVGAGGEVVA EPPIIRTNYL SGWFTLDLLS CLPYEVFKYI
     WPAKNQSIHG LLDGLRIIRL LRIGRAARRI DQYLEYVSTL LLLMILCFFL LAHWFACAWY
     AVGVLDLENK IQYGWIPRYF NDSRVESDEK DGGPKKHAPL QNSVDKWSAY VTALYFSLSL
     LTTIGFGNVA AFTETEKLLS CVCMLIGALV YATIFGNITT IVQELYATRT RYNEIMKGVK
     DFLRIHEVPQ ELGERVIDYI TSSWSVNKGI DTAKVLNYCP KDMQADISVH LNRCVFNSHP
     AFRLASDGCR RSLAVHFQTL HTAPGDLIFH QGESVEYLCF IASGSLEVLQ DDEVIALLGK
     GDVFGDPCWR TTSSIPSAAS VRALTYCTLH TIRLERLRAV LQFYHAFANS FTRNLEVNYN
     LCNRIIFRKL ADVKREMELS MRQNKEPPLS SLPAGHPVRK LISRLRRPSQ NLGTIMSGDS
     SLEGSDLESI SGCVQPETQR PRMSLVNVAR GLVAKTDNDT PAPSSHATTS TMLSSITERV
     SNPSVNIEPQ TVTGAPVMDN TTGAGGTPST TVPQPNPARK WARLISKATQ PRAPNMNTDA
     VDASQQVPSV PTDNKPMVKE VPVTTVADTH VPQSQLAVVP PTSQESTVGI NCSKTTATVM
     VSDAAIKQLG QALQKALGEI HKDLSSQLVD VLGRINNLET QVGTIQNRLA ETDRKKDRHS
     RSQMKKEPQS SNPPTSHSKL TSSKSVEPE
//
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