ID   G7YT69_CLOSI            Unreviewed;       946 AA.
AC   G7YT69;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   28-JUN-2023, entry version 30.
DE   SubName: Full=SH2 domain-containing adapter protein F {ECO:0000313|EMBL:GAA56149.1};
GN   ORFNames=CLF_110122 {ECO:0000313|EMBL:GAA56149.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA56149.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA56149.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA56149.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF144171; GAA56149.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7YT69; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR   PANTHER; PTHR15127:SF32; HEAVYWEIGHT, ISOFORM A; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          837..931
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  102211 MW;  548B044E5E0AA515 CRC64;
     MPSNLEENCG VEFTESEKKG KKSRYSLKKI LHSSRFSPSL LRLTRFTKSI DSDADKDSDR
     VINSELNKTS NDALNKMVIQ QLDAHHPSDR HLTFSASPEL ITAPLCTDPM AFSEPEPDAG
     SEIIVEEYEE SLTHFADMIL ETLKNSGQVP EPSKSQDSGS DLSVSQQSRP RIPSVSPPNM
     AVPWLLNMLS TRSRADTAPP ATITGLHRIQ PGQHVECLNS TGIYNEPCDA KPVRADGSSD
     PTVIYTFSSL RNQLNDALGD PDIEGFRNST ESSPRSSLSN VVESDTRSLH IQSSGIPLGH
     SLSGTRLATK SAEAVARPKS TGSRSDGTIQ LACNTSPPVS HQYQQHQLSQ KNPGFVDGPR
     GNSVIVHHPT SPFARVPRVP TGEPKSDSSV DNSKLHSTPS PSESIPSLIE PISGNTEQPC
     VFQSTLGTIG SSSSQVVSTS GSEAPQSVTD YTVSDKSYLQ TEPSANNSTV RSRTSDAHPT
     YEEAWDLKMT RQLGFGISRL TPAFDRTQQC TPLSNRESKA CFQPTIASPS NLIKSTSSAT
     TSSVGRAVPF SSSLKSTSQQ AVSKPRSNSG ERQCHISAIS SVPTASERVN GKSSLQSYEN
     RLFVEQPKRT ESALTHQTHG PGPAGITSEY DYAYNGSWSM GVKLNLSLAM NQNNETHPGS
     SAHQRTLLPA SGPANHPTAT ISPPAVPAHQ STRTAVNGCK ADAGSVRAKG VTRGPTSALV
     PQEFDSLSTD SCDDSWDKTH GLVVRELTNC RVVDPAAVLP SIGLSHRDAS IIGAPVSTKS
     IGQTSTTVVL PQSICGPQLD RPRSGVLQHS PADLRTPQSW TVRAANLQSL PLEEQPWFHP
     SLTRSDAEEL MSNEPEGSFL VRNSETCIND YSLTIRHKTF LHMKISRNPR GQFILGEYSQ
     PYTSVPQMIY HYASTSVPVR GAEYVMLIHP VCRQITRPLP PPPQPG
//