ID G7YVF3_CLOSI Unreviewed; 1106 AA.
AC G7YVF3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=TBC domain-containing protein kinase-like protein {ECO:0000313|EMBL:GAA56933.1};
GN ORFNames=CLF_111852 {ECO:0000313|EMBL:GAA56933.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA56933.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA56933.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA56933.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF144454; GAA56933.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YVF3; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00158; RHOD; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR22957:SF168; TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00450; RHOD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAA56933.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transferase {ECO:0000313|EMBL:GAA56933.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 747..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..294
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 580..783
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 934..966
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 1106 AA; 122584 MW; 7194211F593D7E2C CRC64;
MDYHLPLGLI HFEVSKPSYT DFESSGLPKL PPSIVSFARL HSLRRLSHRN LCRYVDVIHR
KPERLFVVTE AYRRSLATLS TPVLDAAWLV ARFVECFSAV LYLGEQQMVH CCLTPSIIML
DANDSVKIGG YGMYYATNWG RDVEFPIADP VYSAPEVFLL SAVVAKRRSL CAIVDFSSPC
PLTVQVDVWS LGLIFFELIY GRAVANPLHQ HGDVVTKFAS VNPFLTVRTL LEGLRLSKSK
DLTFPAFLNV SVHCDPAQVL LVRLDDLCRR CMNFNPLLRP IPSEAIIELC PDFITSTVES
HLIGLETCSP ITQQGYFRSP LNSYSATVVP SVIDGSDVSH ETAKAIEFLS SQTDVTELYY
YWQLTGGNLE SVWQEAMRLG TETYNVAQLA AHDVQTGSAN VSSPHCFGVS RCTNPPILRI
PAVLAMMQPL GFMDVPYVVE CPGSMHEAQS PRYHPTPIFL PSQRLLERIS HVPLEVLYPL
LIAFPNRASP AHPHCDFMST DFQLGFLSSA KSIGQLLYQK TPELDEACSH SIASDPMEDQ
PNSVKLTDVE YQVRRVCLFK RLLNGLPSTE KCLRREARKD IPPFLRCQTW AALLGVYKDH
DFRERYSKAL CADAGDATQE QLASRRLDDK AVNQIAVDLP RCHAYDGLLA SPIGQTSLRH
VLISTLLMPP GSLEYTQGMD SVAAVFVRLF HPDQALAAAC LHALFHTKLS GFFSTGGFTT
GLKAFFNVLF RLFAFHAPGL AVSLTNLNVP LVGLTTGWIY TMFAHAMPLD RTELLWDTLI
VGPLSFLMFF YIAIFLQLDQ QVNLQSLGLE KLCTILSNFP DIDLDKCRAD ALRFALATPI
SLTVGPGVNI GGREANPNLP DSVTKSGNAS CPFYERLVIS NAWPEHLEAA ASSDPSWMQT
AGKASPGSEL CNNWVTDNPL VSLLSPDDVL EHILRPDCFV LDVRSREDYL KGCIPGCVHR
PPSQLPLWSN DVESENSSAP PFEWEFVDCP SGDRRQSRVI PAFLAGLITE SAWTKAVEAR
QRAEQRRLGN RTRTQSSVVR NTPGLLLVIG GTEFSSNAKP LEVPVAIQLA DWLIREDVDR
VCVLRGGMPA LLSLPSGRDY LICPGP
//
