ID G8BAB2_CANPC Unreviewed; 365 AA.
AC G8BAB2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN OrderedLocusNames=CPAR2_805340 {ECO:0000313|CGD:CAL0000150499,
GN ECO:0000313|EMBL:CCE41985.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41985.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; HE605205; CCE41985.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BAB2; -.
DR STRING; 578454.G8BAB2; -.
DR EnsemblFungi; CPAR2_805340-T; CPAR2_805340-T-p1; CPAR2_805340.
DR CGD; CAL0000150499; CPAR2_805340.
DR VEuPathDB; FungiDB:CPAR2_805340; -.
DR eggNOG; KOG1339; Eukaryota.
DR Proteomes; UP000005221; Chromosome 8.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..365
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003508175"
FT DOMAIN 59..350
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 77
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 249
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 279..313
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 365 AA; 40907 MW; 21E55310D08DC324 CRC64;
MISLFQGLVL AFIFGVITNG TPVEKRHTKY IAHEFHDTEV RSIGKRAENV DFEDKAWRFV
AHLKIGSAKQ DVQVLLDTAS TVLNVPQTNS TCREGKICAA QNSFNPFEST SFKNSTIPAK
SYFGPNQYTG FIVSDDFYFD DGKRIPQFEF QLLDSYPRDV FGIFGMGYST NNNYTYVLAT
KSAGLINNAG FSLFKNSDKN GSFLLGGVDK AKYDGDLLIF NDSKEAMYPK SIITANGTVI
PFTYKVLHDS GTPTMELLDT VVQKFYKDIG ANDKGHIPCD QVLNGNKSLN FDFGPFTIPV
YYKDIFNRSG STCISNILAT KFPDRQYLGV VFLRNAYLAQ NFDTKKVGLA PVKYTDESDI
VDFWF
//