ID G8BB98_CANPC Unreviewed; 648 AA.
AC G8BB98;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Protein phosphatase PP2A regulatory subunit A {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_808710 {ECO:0000313|CGD:CAL0000148323,
GN ECO:0000313|EMBL:CCE42322.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE42322.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family.
CC {ECO:0000256|ARBA:ARBA00038332}.
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DR EMBL; HE605205; CCE42322.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BB98; -.
DR STRING; 578454.G8BB98; -.
DR EnsemblFungi; CPAR2_808710-T; CPAR2_808710-T-p1; CPAR2_808710.
DR CGD; CAL0000148323; CPAR2_808710.
DR VEuPathDB; FungiDB:CPAR2_808710; -.
DR eggNOG; KOG0211; Eukaryota.
DR Proteomes; UP000005221; Chromosome 8.
DR GO; GO:0005935; C:cellular bud neck; IEA:EnsemblFungi.
DR GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IEA:EnsemblFungi.
DR GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR GO; GO:0110085; C:mitotic actomyosin contractile ring; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:EnsemblFungi.
DR GO; GO:0005816; C:spindle pole body; IEA:EnsemblFungi.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:EnsemblFungi.
DR GO; GO:0061509; P:asymmetric protein localization to old mitotic spindle pole body; IEA:EnsemblFungi.
DR GO; GO:0030952; P:establishment or maintenance of cytoskeleton polarity; IEA:EnsemblFungi.
DR GO; GO:1990813; P:meiotic centromeric cohesion protection in anaphase I; IEA:EnsemblFungi.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:EnsemblFungi.
DR GO; GO:0031030; P:negative regulation of septation initiation signaling; IEA:EnsemblFungi.
DR GO; GO:0006417; P:regulation of translation; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR10648:SF4; PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED; 1.
DR PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 45..82
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 84..121
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 161..198
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 295..327
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 339..377
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 378..416
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 417..455
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 565..602
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 616..648
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 507..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 73540 MW; 507C4AF6B30B5CE7 CRC64;
MDDLYPLALL MDELKHDDVS NRVEAMQKLD TIAIALGPER TRKELLPFLH DVAQDDEEEV
FTVLGAKLGE FIPLIGGHEY CEPLIEILTI LASMEEPLVR DKAIESLNQI SQELNQDEIN
NVFLGLITGL SQGNWFSKKI ASCGLYKAVI IRVDANTRKE LLRTYLKLVT DDYPMVRRAA
ATNLPHLIDL LTKFTEESPN DVNKVNNEDW EIISKMFQHL INDDQDSVKF LSVDVLIAIL
EFFQKIHEYS FNSDFLSSAL KLIKDDSWRV RYTAADRFSK IAINFTHNES DLFQLIDPFI
SLMKDHEGEV RKAIAKQLPG FCKLLTEYPP TKATILNKIV PVVNELSQDP QENVRASLAS
TITELSPILT RQPTIDKLLP IFLTMLKDEF PDVRLNIISN LSVVNETIGI NLLSTNLLPA
ITELAQDHKW RVRLAIIEYI PKLADQLGQS FFNNELLSLC MSWLWDPVFA IREAAVENLK
NLTVIFGSQW ATEEILSRLL NKRNSKMDED GSGVGNGNNT GDENDDDDDD DNKIDYSNFI
IRITCLFAIT SLIPVINYSV LVDKVLPFIN GLITDSVPNI RFNVAKSYLT LVQSLIQQRN
QAPNEDELKK LINLQVLSNL EKLESDEDVD VRFYSTQSIK GINEILAQ
//
