ID G8BBV3_CANPC Unreviewed; 725 AA.
AC G8BBV3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Aminopeptidase P N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_801690 {ECO:0000313|CGD:CAL0000154049,
GN ECO:0000313|EMBL:CCE41618.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41618.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; HE605205; CCE41618.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BBV3; -.
DR STRING; 578454.G8BBV3; -.
DR EnsemblFungi; CPAR2_801690-T; CPAR2_801690-T-p1; CPAR2_801690.
DR CGD; CAL0000154049; CPAR2_801690.
DR VEuPathDB; FungiDB:CPAR2_801690; -.
DR eggNOG; KOG2413; Eukaryota.
DR Proteomes; UP000005221; Chromosome 8.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 95..239
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 438..647
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 660..724
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 725 AA; 82002 MW; 2E2462BC3B8E5E69 CRC64;
MSSFLTEKEP LLARTRKLEE ENEISTHSLS SHTFFKSMFS PFQACFPNNL MQSPNETLVQ
EGDDIIDYSD DDAPLPALPS EQYSHPLSSL SSAERLDGLR KQMRKHNIGV YIIPSEDEHH
SEETALSDRR REFISGFTGS AGVAIVTLTD PDTLSGEAIL STDGRYFLQA QKQLDLKLWK
LNKQNTTGYP LWYQYAVKAA VANEFSNVLS CDPRTLSFAL GEFFRQSPSD FEFRPLSGIN
LVDEVWGSEK PKRSLGPIYV WDLKYSGEHA NAKIKKVRSI LKEKGGTHYL VTELDSIAWL
FNLRADTDIP FAPVFFSYAI VTSTSVALYV DHQKLENSGS ELKKYLSTIE SLTIAEYDEF
YRDASQLQAT VFDPDLRIVL PTKEATSWAL YDAIPDSFSK RHIIHDSIIA NIKIFKNKTE
SHNAKLAQYK DSLAFILFTS WLEHQLINKH AKITEYDASL KIYSIRKNLP NFKGLSYETI
SSTGANAAII HYAPTKDHSD IIDPRKVYLL DSGAHYLEGT TDITRTYLFD KRAVTDELRK
YYTLVLKGHL AVAMAKFPAG SKGTGIVLDS YSRQPLWNHG LDYVHGLGHG VGSFGLVHEG
PLYISPTVND TSKLDLFQPG AILTDEPGFY IDGDVGFRVE SELEITEIDD SFGKTKNGGK
FLGFKYLTKV PFAKSLIDTK YLSEIEIRWI NEYHQSIRED FSDKLLELNN KRAYNWLQKE
TSPIS
//
