ID G8BE64_CANPC Unreviewed; 774 AA.
AC G8BE64;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=mRNA 3'-end-processing protein RNA14 {ECO:0000256|ARBA:ARBA00026188, ECO:0000256|RuleBase:RU369035};
GN OrderedLocusNames=CPAR2_212050 {ECO:0000313|CGD:CAL0000148629,
GN ECO:0000313|EMBL:CCE43561.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE43561.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000256|RuleBase:RU369035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369035}.
CC Cytoplasm {ECO:0000256|RuleBase:RU369035}. Note=Nucleus and/or
CC cytoplasm. {ECO:0000256|RuleBase:RU369035}.
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DR EMBL; HE605206; CCE43561.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BE64; -.
DR STRING; 578454.G8BE64; -.
DR EnsemblFungi; CPAR2_212050-T; CPAR2_212050-T-p1; CPAR2_212050.
DR CGD; CAL0000148629; CPAR2_212050.
DR VEuPathDB; FungiDB:CPAR2_212050; -.
DR eggNOG; KOG1914; Eukaryota.
DR Proteomes; UP000005221; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.1040; -; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980:SF0; CLEAVAGE STIMULATION FACTOR SUBUNIT 3; 1.
DR PANTHER; PTHR19980; RNA CLEAVAGE STIMULATION FACTOR; 1.
DR Pfam; PF05843; Suf; 2.
DR SMART; SM00386; HAT; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU369035};
KW mRNA processing {ECO:0000256|RuleBase:RU369035};
KW Nucleus {ECO:0000256|RuleBase:RU369035};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 487..687
FT /note="Suppressor of forked"
FT /evidence="ECO:0000259|Pfam:PF05843"
FT DOMAIN 695..769
FT /note="Suppressor of forked"
FT /evidence="ECO:0000259|Pfam:PF05843"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 88959 MW; 30817CBA44CB6EB7 CRC64;
MSNPIFITNN KPKTLSLDKI GQLEDDLKIN PLDYNKWIKL LDNVVAKDNQ EQVRKAYEKY
LDIFKFDAAQ WNKYIKYELS RGEKEKAEAL FQKCFAITEN VDLCRSYVDY VRSVTDMITG
GDKARATIIQ AFEFAIDKVG IDVQSGSLWQ DYINFIKSWT PGANWEQQQK IDLIRKVYKK
ALVVPTENIE PLWSQYTKWE NELNQATAQK FVSEKSAEFM AARSWNTEWQ NLTKKKLKRS
IIPHGLDNDL VEAQMKYWAS WLQLEKKNSL QIKDESLLQR RINYVYKEAT YALPFVSQLW
FEYVKHLLND NEESNLSKCI SILNDGLKLN PKSLLLSFQL AELYEKDNTF NDAKVIYNQL
IANLTEDHKK VTEKLNGLYD RISPGTNDKN EEDDHMNNEE DENEMGGANV VHVLTNGKSN
GHGNPNLPPK PNIPCLPQIP NNLAPVSDVD DSTLTKPDLV SSKLSGTERK TFLKLKKERD
QLVDTISLTY IKFMVASKRA EGMKEARDVF RQARKNDSVG YQIYVENALL EHYADNKKTA
LKVFGIGQKA FPTNGNFLFK FLDYLIMTND VDKLRSTIQS SDTNISKEIT QITEELTFAG
LDPVLTEEKE QKLNSQKTFL KRLYKRYISF SANYLSLDIT SSFAKKYEQL FPDDDPVDLF
TDRYKLDVVN IIKRDELNRD DHVDYADLSR KKRKVSFGFD NTESTSAVKS IQESRRIEQE
VMEDEQSNGA SFVGPSIVAL MSALPNASYF GLPSESVFNS DKLVTLFSNL PNIA
//
