ID G8BG05_CANPC Unreviewed; 1917 AA.
AC G8BG05;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN OrderedLocusNames=CPAR2_204320 {ECO:0000313|CGD:CAL0000149231,
GN ECO:0000313|EMBL:CCE42789.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE42789.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; HE605206; CCE42789.1; -; Genomic_DNA.
DR STRING; 578454.G8BG05; -.
DR EnsemblFungi; CPAR2_204320-T; CPAR2_204320-T-p1; CPAR2_204320.
DR CGD; CAL0000149231; CPAR2_204320.
DR VEuPathDB; FungiDB:CPAR2_204320; -.
DR eggNOG; KOG0902; Eukaryota.
DR Proteomes; UP000005221; Chromosome 2.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1361..1545
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1638..1901
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 472..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1917 AA; 218004 MW; 9E7408924CCD3885 CRC64;
MDFYGITRGT IRGEALKKLA ELTVEHVPSN LKEINTGIQK DDFAKLLTST PRDLPLRKSI
GSSINDQKMS NVAIAPKEYE TLVALCDATD KPIKLTSQIK TLIDKFRVYL FELPDQQFAY
SIVAKSVAVA PWTLLGEKLT IALINLAYQS NKQYFDEVVE VFHQFIDKFF DNVDLQLSNF
LTLTGVIDGL NQNAQFLTYS SRTFRIFTNL DSAIDNSEIL GAIEDYSDYL YDDPNPYQEL
LERDFCLNFS PVLYLEKLSR LMCSILVEIV ASKSQHLLPY LLTQAAKKYD EDESNGRAII
GPGRDHLSFP RAHMEIIKIL TDLALRKLEF LDRGETYIVY STNNRLKLGY LAKSFNLQVL
SCGMFTDNLD LATSKELFKA NIEIKDAMLD PDLGLTTFQF GSLLVFKDES IGPLLTRVFT
SVIANPRLES SYCLEASKCV GLGSKRLPQD AVVTTIYSLT NLLFVTNEGL QGPSKSARRA
ARNHTGGADN ASTRDFVSSP LSSSRTSMTS FSQLFSKGSL SGDFDENDYQ KVCENAVTAI
IEVSEACDDE SIPALACTIL SQKVTKVESP IGPLILRGLC SCAPYVPERE FIILIRLLNK
LTVDSFERKN ATLLGHLNES RLILSSKLKP DNHLYFVYLH ELLQSIISKG DVQQLEHHRS
HNEISEVGDQ IAIYLKPLAE LLPDVHLGQE PLKIEKTETI NLFRNIWFNM VVHGYNLNSK
NTKVFKDELE RIAYNSPPLA SERSWDRTET SIELNTVLRR GSSNHNIKDH KTFLGDIFEV
HRTMSYPKLM FLSATVFCET LRVRTGDCSK ILYYFTDPTS KISGIDKYLG PIAFKIVRDY
IGLINTGANK QFTADHIANQ LTTMLTLTTH PVTEMQDASI QCCDLLINKV SASLCHKKSL
FALFDILTLL FQSIADADVH EYDPTTSFRA RCTGIKITLS DDYDWRCSTF NRFHEKAKGW
VELLLYKSNI DVKSLIQSYV AANEELQYEA PIQFGLSFAL KMSGTISSHD RDIQAITYAN
ISALDTTPSI VSQLNWRSNF VSQFMNKLPL RTDEESDFAF KAIREKVYNI KSRLFNEFTE
NPSHDEIMNL LTEIAGLTLL SDINNAELVR YMVEIPFILF EPSVMIPASG VWFAVMKDKP
KLSMLLLSEL AQKWEESIEL RKGLFSQELD IVHPEFDKME YAPSNRSTDL RLAENAQRSF
EPHLELVRLF SSNFEATLNQ SDHLLKLFTR FVEVGLKNLK FASYHPLSRL VRFELVRFAF
EVLQVHLKLG SRICKYLTEL IFDGALTWFR QRFVYPFSAN KLKFKSEAIV MNEVARMAGA
VSVFRSKDIE MKRTIFLQFL DDEVYKFNVW LTSLNPTDTS GSIIGSSHQV SSTQITRAYE
IDPILAINLA MRYKSKAHDD LIQQLIIKNP LAAIPYPDAV QFFIGINLGV HMPSHQLLFW
SPVAPIDAIT LFLPPFGANP YILQYTMRSL ETHDVNLTFF YVPQIVQSLR HDAKGYVERF
IIETAKVSQL FAHQIIWNML ANSYKDDDST EPDDLKPVLD RIQEHMLKEL SDKDLQFYHK
EFGFFNEVTD ISGKLKPYIK KSKAEKKAKI DEEMALIKVE PGVYLPSNPD GVLVDINRKS
GKPLQSHAKA PFMATFKIKK ELTDYDEHGK PQQVEIEKWQ SAIFKVGDDC RQDVLALQLI
SMFRTIWSDA GLDLYVYPYR VTATAPGCGV IDVLPNANSR DMLGREAVNG LFEYYITKFG
PQKSIEFQKA RNNLVKSLAA YSIISYLLQF KDRHNGNIMY DDQGHILHID FGFCFDIVPG
GVKFEAAPFK LTHEMVMVLG GSDDTQAFKW FEELCIKGYL ACRPYMELIV RTVVPMLESG
LPCFKDTTIK NLRSRFVPGK SDKEAAVYFR KLIKKSMESF YTKGYDEFQR ITNGIPY
//
