ID G8BJA5_CANPC Unreviewed; 317 AA.
AC G8BJA5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Protein CCC1 {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_405240 {ECO:0000313|CGD:CAL0000147331,
GN ECO:0000313|EMBL:CCE44720.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE44720.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CCC1 family.
CC {ECO:0000256|ARBA:ARBA00007049}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE605208; CCE44720.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BJA5; -.
DR STRING; 578454.G8BJA5; -.
DR EnsemblFungi; CPAR2_405240-T; CPAR2_405240-T-p1; CPAR2_405240.
DR CGD; CAL0000147331; CPAR2_405240.
DR VEuPathDB; FungiDB:CPAR2_405240; -.
DR eggNOG; KOG4473; Eukaryota.
DR Proteomes; UP000005221; Chromosome 4.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:EnsemblFungi.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:EnsemblFungi.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:EnsemblFungi.
DR CDD; cd02435; CCC1; 1.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851; FE(2+)/MN(2+) TRANSPORTER PCL1; 1.
DR PANTHER; PTHR31851:SF52; PROTEIN CCC1; 1.
DR Pfam; PF01988; VIT1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 34006 MW; 09DE37120D205A1A CRC64;
MSLVALKNGV ASVLSKKNSS DEELERANRL LENNSLPYGS TDNNGNNSDD RAAEIAREEA
VIHAAASIAS SSANKEEEEA NNSFLTNFFN RFDPRVMSDI IIGLSDGLTV PFALTAGLSS
LGDSKLVITG GMAELVSGAI SMGLGGFLAA KSESEYYNSQ VKKEKLSFFK KPETVNQDAA
EIMFELGASE QTIISFLKDL DSKPKNLIDF IIRFGRGLEE PAEGREFTSA MTIGSAYFLG
GFVPLLPYFF TNVVKTGLLI SVIVMLITLF IFGFIKTSIS LGDDCGNHKK VAEGFQMVAV
GSVAAGAAWG LVYLIDN
//
