ID G8BU93_TETPH Unreviewed; 265 AA.
AC G8BU93;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Cytidyltransferase-like domain-containing protein {ECO:0000259|Pfam:PF01467};
GN Name=TPHA0E03820 {ECO:0000313|EMBL:CCE63471.1};
GN OrderedLocusNames=TPHA_0E03820 {ECO:0000313|EMBL:CCE63471.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE63471.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE63471.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate
CC + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001084};
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004790}.
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DR EMBL; HE612860; CCE63471.1; -; Genomic_DNA.
DR RefSeq; XP_003685905.1; XM_003685857.1.
DR AlphaFoldDB; G8BU93; -.
DR STRING; 1071381.G8BU93; -.
DR GeneID; 11531188; -.
DR KEGG; tpf:TPHA_0E03820; -.
DR eggNOG; ENOG502RXY8; Eukaryota.
DR HOGENOM; CLU_032651_0_0_1; -.
DR OMA; RLVMMEL; -.
DR OrthoDB; 1331302at2759; -.
DR UniPathway; UPA00253; UER00600.
DR Proteomes; UP000005666; Chromosome 5.
DR GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02165; NMNAT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR005248; NadD/NMNAT.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR31285; NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE; 1.
DR PANTHER; PTHR31285:SF0; NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666}.
FT DOMAIN 42..234
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 265 AA; 30381 MW; 469AA6A2C315263F CRC64;
MDILKLQLVE KYKSFIDSNQ DFKVVYGDNL LDSQNDVILV LDSSFNPPHM GHYSLAKRSI
EYFKEHHKNS KVSLLLLLSV KNADKVPTPA SFEERLYMMC LLNDFIKKDG IKVSVGLTTH
AKFVDKSDAI RRACSFENQI AYLVGFDTIT RIFDPRYYKP DAPADALQEF MKTTQFCCLT
RDNGSIPSEE QLNYASDISS GKFEPLIPSH WGSKIHILDN DSKYTKISSS DIRNKLHNIS
RVKELNDELP LTIMEYLEVF GKSIY
//
