ID G8CUP5_CATRO Unreviewed; 361 AA.
AC G8CUP5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=CAD2 protein {ECO:0000313|EMBL:AYE56097.1};
DE SubName: Full=Cr2141 {ECO:0000313|EMBL:AEO99200.1};
OS Catharanthus roseus (Madagascar periwinkle) (Vinca rosea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae;
OC Catharanthinae; Catharanthus.
OX NCBI_TaxID=4058 {ECO:0000313|EMBL:AEO99200.1};
RN [1] {ECO:0000313|EMBL:AEO99200.1}
RP NUCLEOTIDE SEQUENCE.
RA Usera A.R., Yerkes N.M., Liscombe D.K., Nims N.E., O'Connor S.E.;
RT "Chemoenzymatic Synthesis of a Photo-Affinity Probe for Enzyme
RT Identification in Plants.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AYE56097.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30256480;
RA Qu Y., Safonova O., Luca V.;
RT "Completion of the canonical pathway for assembly of anticancer drugs
RT vincristine/vinblastine in Catharanthus roseus.";
RL Plant J. 97:257-266(2019).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; HQ380174; AEO99200.1; -; mRNA.
DR EMBL; MH194346; AYE56097.1; -; mRNA.
DR AlphaFoldDB; G8CUP5; -.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF65; CINNAMYL ALCOHOL DEHYDROGENASE 8; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 24..352
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 361 AA; 38411 MW; 67FEBBA810A2F72E CRC64;
MAGKSPEEEH PVKTYGLAAH DSSGVLSPFK FSRRATLEDD VRFKVLYCGI CHTDLHFAKN
EWGISTYPLV PGHEIVGEVT EVGGKVTKVK VGDKVGVGCL VGSCRTCDNC RADLENYCPK
MVLTYASPNV DGTITYGGYS NEMVCNEHFI VRFPENLPLD GGAPLLCAGI TVYSPMKYYG
FAKPGSHIAV NGLGGLGHVA VKFAKAMGAK VTVISTSEGK KDDALNRLGA DAFLLSSNPE
ALQAATGTFD GILNTISAKH AIIPLLGLLK SHGKLVLLGA PPEPLDLHSA PLLMGRKMVA
GSSIGGLKET QEMLDFAGKH NITADIELIS ADNINTALER LAKGDVRYRF VLDVAKTLKA
P
//
