ID G8E836_9VIRU Unreviewed; 787 AA.
AC G8E836;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE SubName: Full=Putative serine protease {ECO:0000313|EMBL:AER41412.1};
OS Astrovirus MLB2.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae.
OX NCBI_TaxID=683172 {ECO:0000313|EMBL:AER41412.1, ECO:0000313|Proteomes:UP000122431};
RN [1] {ECO:0000313|Proteomes:UP000122431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22099095;
RA Holtz L.R., Wylie K.M., Sodergren E., Jiang Y., Franz C.J., Weinstock G.M.,
RA Storch G.A., Wang D.;
RT "Astrovirus MLB2 Viremia in Febrile Child.";
RL Emerg. Infect. Dis. 17:2050-2052(2011).
CC -!- FUNCTION: Protein covalently attached to the 5' extremity of the
CC genomic and subgenomic RNAs. {ECO:0000256|ARBA:ARBA00029406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC Evidence={ECO:0000256|ARBA:ARBA00024586};
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DR EMBL; JF742759; AER41412.1; -; Genomic_RNA.
DR RefSeq; YP_004934008.1; NC_016155.1.
DR MEROPS; S01.109; -.
DR GeneID; 11933343; -.
DR KEGG; vg:11933343; -.
DR OrthoDB; 507at10239; -.
DR Proteomes; UP000122431; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR045836; Astro_VPg.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF19416; Astro_VPg; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:AER41412.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 787 AA; 88883 MW; 66D690C899F3F992 CRC64;
MAVPFHIGVA DKVLALGSSR SRMWLNELSP AVQNQLRDIF PYEVPLNTMI VPFSRYSMGT
GVTLAVQGIT TPGVYSTYVL HGESWLEVDE ERVEPACAFV GALAVDRTKL AERNRELQND
NASIIVENQL LRHEVERLRP PATRPVRFSN FALFVLFFFL FFIIGTKAEN WQDQTKDYVI
DFLRDVKYEF ISNLDIYYSV LLNLIRWEVI SCVIAIVSFF KLKRPCVAII GLFLATISRY
NYSALSIVPY LDIYSTAFLY VLMVVYFLVP HVAIVTSVVC AMLFTIVSMV CPHHQFIMRV
RGDWLVVLVT IATYICDSMG IHTTAIAIMA AVARIYMCMP ATTASVVEIK DNTGKVVQKT
TLMPNWIGTM YQSARGMFQR VRTGVASFVR VNPNCLCHIK VDGCSGTGFR LGNDIVTAAH
VIGNATQVEV VYNNYVAQAK VRHIPDKDIA YLVLPEGLKS MPVLKLARTP SYEQVTIIAL
EGNCMLVSTT EGVCHGETIS YACATRDGMS GAPVLDVNGN VLGVHQTNTG YTGGATVIRA
TDAAPYVDEN AALKKEIEEL KRIIKENAMQ QRSVQDNEVV GIVRAAVQRE IGILRDELNS
CYQKKKGKNK KGRGARHRML RRGQKFLTEE EYQELLDKGL TREQLLDAIE EIVRSRIGFP
DWSDPEYSSE EDDAAVTYWW EQVKEDNYKD GIPQFDHIIP KYSPSERTFS EQERKDVARE
LDALQSVVDK VNKDEWDEKK KQITDELNHA LFVVDKALAQ HGYILFEQRM RPKNGKRGPR
RRTPNTT
//
