ID G8F1Z8_MACMU Unreviewed; 1537 AA.
AC G8F1Z8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE SubName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein {ECO:0000313|EMBL:EHH25647.1};
GN ORFNames=EGK_21552 {ECO:0000313|EMBL:EHH25647.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH25647.1, ECO:0000313|Proteomes:UP000013456};
RN [1] {ECO:0000313|EMBL:EHH25647.1, ECO:0000313|Proteomes:UP000013456}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH25647.1,
RC ECO:0000313|Proteomes:UP000013456};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; JH292322; EHH25647.1; -; Genomic_DNA.
DR Proteomes; UP000013456; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 1..65
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 96..217
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 246..321
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 354..422
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 621..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1537 AA; 172025 MW; BC824AD4A94A54BE CRC64;
MLLGGRKTTD IPLEGYLLSP IQRICKYPLL LKELAKRTPG KHPDHPAVQS ALQAMKTVCS
NINETKRQME KLEALEQLQS HIEGWEGSNL TDICTQLLLQ GTLLKISAGN IQERAFFLFD
NLLVYCKRKS RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV
TNGWKIHNTA KNKWFVCMAK TAEEKQKWLD AIIREREQRE SLKLGMERDA YVMIAEKGEK
LYHMMMNKKV NLIKDRRRKL STVPKCFLGN EFVAWLLEIG EISKTEEGVN LGQALLENGI
IHHVSDKHQF KNEQVMYRFR YDDGTYKARS ELEDIMSKGV RLYCRLHSLY TPVIKDRDYH
LKTYKSVLPG SKLVDWLLAQ GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FRDESQYFRF
HADEEMEGTS SKNKQLRNDF KLVENILAKR LLILPQEEDY GFDIEEKNKA VVVKTVQRGS
LAEVAGLQVG RKIYSINEDL VFLRPFSEVE SILNQSFCSR RPLRLLVATK AKEIIKIPDQ
PDTLCFQIHG AAPPYVYAVG RGSEAMAAGL CAGQCILKVN GSNVMNDGAP EVLDHFQAFR
SRREEALGLY QWIYHTHEDA QEARASQEAA SEDPSGEQAQ EEDQPDSAFP LLSLGPRLSL
CEDSPMVSLT VDNVHLEHGV VYEYILEAFA ADDSVFVENC GRLMALSSAI VTMPHFEFRN
ICDTKLESIG QRIACYQEFA AQLKSRVSPP FKQAPLEPHP LCGLDFCPTN CHINLMEVSY
PKTTPSVGRS FSIRFGRKPS LIGLDPEQGH LNPMSYTQHC ITTMAAPSWK CLPAEEGDPQ
GQGLHDGSFG PASGTLGQED RGLSFLLKQE DREIQDAYLQ LFTKLDVALK EMKQYVTQIN
RLLSTITEPT SGGSCDASLA EEASSLPLVS EESEMDRSDH GGIKKVCFKV AEEDQEDSGH
DTMSYRDSYS ECNSNRDSVL SYTSVRSNSS YLGSDEMGSG DELPCDMRIP SDKQDKLHGC
LEHLFNQGRG AQTNPGLLAS QVDSINALLK GPVMSRAFEE TKHFPMNHSL QEFKQKEECT
IRGRSLIQIS IQEDPWNLPN SIKTLVDNIQ RYVEDGKNQL LLALLKCTDT ELQLRRDAIF
CQALVAAVCT FSEQLLAALG YRYNNNGEYE ESSRDASRKW LEQVAATGVL LHCQSLLSPA
AVKEERTMLE DIWVTLSELD NVTFSFKQLD ENYVANTNVF YHIEGSRQAL KVIFYLDSYH
FSKLPSRLEG GASLRLHTAL FTKALENVEG LPSPGSQAAE DLQQEINAQS LEKVQQYYRK
LRAFYLERSN LPTDASTTVV KIDQLIRPIN ALDELCRLMK SFVHPKPGAA GSVGAGLIPI
SSELCYRLGA CQMVMCGTGM QRSTLSVSLE QAAILARSHG LLPKCIMQAT DIMRKQCASS
RALNLQRPRP DGSFFQGPRV EILAKNLRVK DQMPQGAPRK MSKAPRCAMG GGSVPSSHLT
ATVPSAPCPV SPEPRPMPST LCRMPCAPHP VPPTLSP
//
