ID G8F2B1_MACFA Unreviewed; 789 AA.
AC G8F2B1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Nuclear autoantigenic sperm protein {ECO:0000256|ARBA:ARBA00021576};
GN ORFNames=EGM_19777 {ECO:0000313|EMBL:EHH61425.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN [1] {ECO:0000313|EMBL:EHH61425.1, ECO:0000313|Proteomes:UP000009130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH61425.1,
RC ECO:0000313|Proteomes:UP000009130};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NASP family.
CC {ECO:0000256|ARBA:ARBA00008402}.
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DR EMBL; JH329992; EHH61425.1; -; Genomic_DNA.
DR AlphaFoldDB; G8F2B1; -.
DR eggNOG; KOG4563; Eukaryota.
DR Proteomes; UP000009130; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR019544; Tetratricopeptide_SHNi-TPR_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15081:SF1; NUCLEAR AUTOANTIGENIC SPERM PROTEIN; 1.
DR PANTHER; PTHR15081; NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED; 1.
DR Pfam; PF10516; SHNi-TPR; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 543..576
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 546..579
FT /note="Tetratricopeptide SHNi-TPR"
FT /evidence="ECO:0000259|Pfam:PF10516"
FT REPEAT 585..618
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 117..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..660
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 153..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 86141 MW; E14FC2C93ADCA008 CRC64;
MFLLLLHLQI KWRATINLLS VTEDGLHFVE YYLNTIIYLD VDSEAKKLLG LGQKHLVMGD
IPAAVNAFQE AASLLGKKYG ETANECGEAF FFYGKSLLEL ARMENGVLGN ALEGVHVEEE
EGEKTEDESL AENNDNIDEE AREELREQVY DAMGEKEEAK KTEDKSLAKP ETNKEQDSEV
KKGGREDMDI SESAEEPQEK VDLTLDWLTE TSEEAKGGTA PEGPNEAEVT SGKPEQEAPD
AEEEKSVSGT DVQEECRGKG QEKQGEVIVS MEEKPKEVSE EQPVVTVEKQ GTAVELEAES
LDPTVKPVDV GGDEPEEKVV TSEHEAGKVV LEQLVGQEVP PAEESPEVTT EAAEASAVEA
GSEVSEKPGQ EATVLPKDGA VNGPSAVGDQ TPIEPQTSIE RLTETKDGSG LEEKVRAKLV
PSQEETKLSV EESEAAGDGV DTKVAQGATE KSTEDKVQIA ANEETQEREE QMKEGEETEG
SEEDDKENDK TEEMPNDSVL ENKSLQENEE EEIGNLELAW DMLDLAKIIF KRQETKEAQL
YAAQAHLKLG EVSVESENYV QAVEEFQSCL NLQEQYLEAH DRLLAETHYQ LGLAYGYNSQ
YDEAVAQFSK SIEVIEKRMA VLNEHVKEAE GLSAEYKKEI EELKELLPEI REKIEDAKES
QHSGNVAELA LKATLVESST SGFTPSGGGS SVSMIAGRKP TDGASSSNCV TDISHLVRKK
RKPEEESPRK DDAKKAKPEP EVNGGSGDAV PSGNEVSENM EEEAENRAES RAAVEATVEA
GATVESTAC
//
