ID G8F590_MACFA Unreviewed; 215 AA.
AC G8F590;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Fanconi anemia-associated protein of 24 kDa {ECO:0000313|EMBL:EHH62454.1};
GN ORFNames=EGM_20790 {ECO:0000313|EMBL:EHH62454.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN [1] {ECO:0000313|EMBL:EHH62454.1, ECO:0000313|Proteomes:UP000009130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62454.1,
RC ECO:0000313|Proteomes:UP000009130};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; JH331401; EHH62454.1; -; Genomic_DNA.
DR AlphaFoldDB; G8F590; -.
DR SMR; G8F590; -.
DR eggNOG; KOG2841; Eukaryota.
DR OrthoDB; 2906428at2759; -.
DR Proteomes; UP000009130; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0071821; C:FANCM-MHF complex; IEA:Ensembl.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR CDD; cd20076; XPF_nuclease_FAAP24; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR026985; FAAP24.
DR InterPro; IPR040646; PND.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR31786; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR PANTHER; PTHR31786:SF2; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF17949; PND; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT DOMAIN 12..134
FT /note="Fanconi anemia core complex-associated protein 24
FT pseudonuclease"
FT /evidence="ECO:0000259|Pfam:PF17949"
FT DOMAIN 166..214
FT /note="DisA/LigA helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF12826"
SQ SEQUENCE 215 AA; 24038 MW; A39B5A2B5204800A CRC64;
MEKKPPDDTG PVHVPLGHIV ANEKWRGSQL AQEMQGKIKL IFEDGLTPDF YLSNRCCVLY
VTEADLVAGN GYRKRLVRVR NSGNLQGIVV VEKTRMSEQY FPALQKFTVL DLGMVLLPVA
SQMEASCLVI QLVQEQTKEP SKNPLLRKKR ALLLSEPSLL RTVQQIPGVG KVKAPLLLQK
FPSIQQLSNA SIRELEQVVG QAVAKQIHAF FTQPR
//
