ID G8GA33_9PLVG Unreviewed; 158 AA.
AC G8GA33;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AER39939.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AER39939.1};
OS Simian-Human immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Primate lentivirus group.
OX NCBI_TaxID=57667 {ECO:0000313|EMBL:AER39939.1};
RN [1] {ECO:0000313|EMBL:AER39939.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M04008wk13-10 {ECO:0000313|EMBL:AER39939.1};
RX PubMed=21084490; DOI=10.1128/JVI.01701-10;
RA Kearney M., Spindler J., Shao W., Maldarelli F., Palmer S., Hu S.L.,
RA Lifson J.D., KewalRamani V.N., Mellors J.W., Coffin J.M., Ambrose Z.;
RT "Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse
RT transcriptase persists in macaques despite antiretroviral therapy.";
RL J. Virol. 85:1067-1076(2011).
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DR EMBL; JN113715; AER39939.1; -; Other_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 1..158
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AER39939.1"
FT NON_TER 158
FT /evidence="ECO:0000313|EMBL:AER39939.1"
SQ SEQUENCE 158 AA; 18271 MW; 5C995236B26F90E0 CRC64;
EGKISKIGPE NPYNTPVFAI KKKDSTKWRK LLDFRELNKR TQDFWEVQLG IPHPAGLKKK
KSVTVLDVGD AYFSVPLDED FRKYTAFTIP SINNETPGIR YQYNVLPQGW KGSPAIFQSS
MTKILEPFRK QNPDIVIYQY MDDLYVGSDL EIGQHRTK
//
