ID G8H6N7_HYDVU Unreviewed; 794 AA.
AC G8H6N7; T2MGP4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=ERCC3 {ECO:0000313|EMBL:CDG71279.1};
GN Synonyms=LOC100208821 {ECO:0000313|RefSeq:XP_012562664.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:AER00321.2};
RN [1] {ECO:0000313|EMBL:AER00321.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RA Barve A.M., Ghaskadbi S.S., Ghaskadbi S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDG71279.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG71279.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
RN [3] {ECO:0000313|EMBL:AER00321.2, ECO:0000313|RefSeq:XP_012562664.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RX PubMed=23577191;
RA Barve A., Ghaskadbi S., Ghaskadbi S.;
RT "Conservation of the nucleotide excision repair pathway: characterization
RT of hydra xeroderma pigmentosum group f homolog.";
RL PLoS ONE 8:E61062-E61062(2013).
RN [4] {ECO:0000313|EMBL:AER00321.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RA Galande A.A., Barve A., Ghaskadbi S.S., Ghaskadbi S.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:XP_012562664.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; JN411718; AER00321.2; -; mRNA.
DR EMBL; HAAD01005047; CDG71279.1; -; mRNA.
DR RefSeq; NP_001296689.1; NM_001309760.1.
DR RefSeq; XP_012562664.1; XM_012707210.1.
DR EnsemblMetazoa; NM_001309760.1; NP_001296689.1; LOC100208821.
DR EnsemblMetazoa; XM_012707210.1; XP_012562664.1; LOC100208821.
DR GeneID; 100208821; -.
DR KEGG; hmg:100208821; -.
DR OMA; RCQEIDY; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000313|EMBL:CDG71279.1,
KW ECO:0000313|RefSeq:XP_012562664.1};
KW Helicase {ECO:0000313|EMBL:CDG71279.1, ECO:0000313|RefSeq:XP_012562664.1};
KW Hydrolase {ECO:0000313|EMBL:CDG71279.1, ECO:0000313|RefSeq:XP_012562664.1};
KW Nucleotide-binding {ECO:0000313|EMBL:CDG71279.1,
KW ECO:0000313|RefSeq:XP_012562664.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694840}.
FT DOMAIN 342..503
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 557..717
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 90783 MW; F706BFC044DB6258 CRC64;
MGKHKKRKLD EKESKSAKKR KEDEDENDFS EDDQEESNSL NANNAAVPNA ANRKVGDIND
NLDEYGAKDY RKIVSLKADH QSRPLWVAPD GHIFLESFSA VYKHAHDFLI TIAEPVCRPK
FIHEYKLTAY SLYAAVSVGL QTKDIIEYLT RLSKTTIPEG IVQFIELCTI SYGKVKLVLK
HNRYYVESNF PDALQQLLKD PEIQMCRALS KDDGSNGELI SSKIGTHNAL KLNHSQINKD
TNVPNEQEKQ EEEKESIPSD IADYLGKVMM DEDDEAEEPV NTVSFEVAQE HIEVLQKRCI
ALDYPLLAEY DFTNDTINKD INMDLKPSTL LRPYQEKSLR KMFGNGRARS GVIVLPCGAG
KTLVGVTAAC TVRKKCLVLC TSGVSVEQWK SQFKLWANID DKHICRFTSD TKDKPVDCHL
AVTTYSMIAH TMKRSYESTL IMDFLKNTEW GLMLLDEVHT IPAKQFRRVL TIVNAHCKLG
LTATLVREDD KIQDLNFLIG PKLYEANWME LQNNGYLARV QCAEVWCPMS PEFYREYLSI
PSRKRSLFYV MNPNKFRACE FLIRFHERRN DKIIVFADNV FALKHYAVKL NKPFIYGPTS
QNERLHIIQN FVHNPLVNTI FISKVGDTSF DMPEANVLIQ ISSHGGSRRQ EAQRLGRILR
AKKDMAAEEY NAFFYSLVST DTEEMFFSNK RQRFLINQGY SYKVITKLAG MDEESLSYSN
KKEHHELLQK VLAATDTDAE EEKIPGDSAN KSGNLSVVRR QGSMASMSGA DDMVYSEYSG
KTKSRHPLFK RFRL
//