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Database: UniProt
Entry: G8H6N7_HYDVU
LinkDB: G8H6N7_HYDVU
Original site: G8H6N7_HYDVU 
ID   G8H6N7_HYDVU            Unreviewed;       794 AA.
AC   G8H6N7; T2MGP4;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   Name=ERCC3 {ECO:0000313|EMBL:CDG71279.1};
GN   Synonyms=LOC100208821 {ECO:0000313|RefSeq:XP_012562664.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:AER00321.2};
RN   [1] {ECO:0000313|EMBL:AER00321.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RA   Barve A.M., Ghaskadbi S.S., Ghaskadbi S.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDG71279.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG71279.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
RN   [3] {ECO:0000313|EMBL:AER00321.2, ECO:0000313|RefSeq:XP_012562664.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RX   PubMed=23577191;
RA   Barve A., Ghaskadbi S., Ghaskadbi S.;
RT   "Conservation of the nucleotide excision repair pathway: characterization
RT   of hydra xeroderma pigmentosum group f homolog.";
RL   PLoS ONE 8:E61062-E61062(2013).
RN   [4] {ECO:0000313|EMBL:AER00321.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ind-Pune {ECO:0000313|EMBL:AER00321.2};
RA   Galande A.A., Barve A., Ghaskadbi S.S., Ghaskadbi S.;
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|RefSeq:XP_012562664.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
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DR   EMBL; JN411718; AER00321.2; -; mRNA.
DR   EMBL; HAAD01005047; CDG71279.1; -; mRNA.
DR   RefSeq; NP_001296689.1; NM_001309760.1.
DR   RefSeq; XP_012562664.1; XM_012707210.1.
DR   EnsemblMetazoa; NM_001309760.1; NP_001296689.1; LOC100208821.
DR   EnsemblMetazoa; XM_012707210.1; XP_012562664.1; LOC100208821.
DR   GeneID; 100208821; -.
DR   KEGG; hmg:100208821; -.
DR   OMA; RCQEIDY; -.
DR   OrthoDB; 1360679at2759; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd18029; DEXHc_XPB; 1.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001161; XPB/Ssl2.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   NCBIfam; TIGR00603; rad25; 1.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   PRINTS; PR00851; XRODRMPGMNTB.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000313|EMBL:CDG71279.1,
KW   ECO:0000313|RefSeq:XP_012562664.1};
KW   Helicase {ECO:0000313|EMBL:CDG71279.1, ECO:0000313|RefSeq:XP_012562664.1};
KW   Hydrolase {ECO:0000313|EMBL:CDG71279.1, ECO:0000313|RefSeq:XP_012562664.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:CDG71279.1,
KW   ECO:0000313|RefSeq:XP_012562664.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694840}.
FT   DOMAIN          342..503
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          557..717
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   794 AA;  90783 MW;  F706BFC044DB6258 CRC64;
     MGKHKKRKLD EKESKSAKKR KEDEDENDFS EDDQEESNSL NANNAAVPNA ANRKVGDIND
     NLDEYGAKDY RKIVSLKADH QSRPLWVAPD GHIFLESFSA VYKHAHDFLI TIAEPVCRPK
     FIHEYKLTAY SLYAAVSVGL QTKDIIEYLT RLSKTTIPEG IVQFIELCTI SYGKVKLVLK
     HNRYYVESNF PDALQQLLKD PEIQMCRALS KDDGSNGELI SSKIGTHNAL KLNHSQINKD
     TNVPNEQEKQ EEEKESIPSD IADYLGKVMM DEDDEAEEPV NTVSFEVAQE HIEVLQKRCI
     ALDYPLLAEY DFTNDTINKD INMDLKPSTL LRPYQEKSLR KMFGNGRARS GVIVLPCGAG
     KTLVGVTAAC TVRKKCLVLC TSGVSVEQWK SQFKLWANID DKHICRFTSD TKDKPVDCHL
     AVTTYSMIAH TMKRSYESTL IMDFLKNTEW GLMLLDEVHT IPAKQFRRVL TIVNAHCKLG
     LTATLVREDD KIQDLNFLIG PKLYEANWME LQNNGYLARV QCAEVWCPMS PEFYREYLSI
     PSRKRSLFYV MNPNKFRACE FLIRFHERRN DKIIVFADNV FALKHYAVKL NKPFIYGPTS
     QNERLHIIQN FVHNPLVNTI FISKVGDTSF DMPEANVLIQ ISSHGGSRRQ EAQRLGRILR
     AKKDMAAEEY NAFFYSLVST DTEEMFFSNK RQRFLINQGY SYKVITKLAG MDEESLSYSN
     KKEHHELLQK VLAATDTDAE EEKIPGDSAN KSGNLSVVRR QGSMASMSGA DDMVYSEYSG
     KTKSRHPLFK RFRL
//
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