ID G8H9C0_HHV1 Unreviewed; 550 AA.
AC G8H9C0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Envelope glycoprotein E {ECO:0000256|ARBA:ARBA00013988};
GN Name=US8 {ECO:0000313|EMBL:AER38072.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:AER38072.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AER38072.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OD4 {ECO:0000313|EMBL:AER38072.1};
RX PubMed=22016062; DOI=10.1167/iovs.11-7812;
RA Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.;
RT "Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes:
RT phylogeny, sequence variability, and SNP distribution.";
RL Invest. Ophthalmol. Vis. Sci. 52:9061-9073(2011).
RN [2] {ECO:0000313|EMBL:AKH80538.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=81L {ECO:0000313|EMBL:AKH80538.1};
RX PubMed=25855744; DOI=10.1128/JVI.00416-15;
RA Kolb A.W., Larsen I.V., Cuellar J.A., Brandt C.R.;
RT "Genomic, phylogenetic, and recombinational characterization of herpes
RT simplex virus 2 strains.";
RL J. Virol. 89:6427-6434(2015).
RN [3] {ECO:0000313|EMBL:AKG59248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=10-1-2 {ECO:0000313|EMBL:AKG61269.1}, 10-2-2
RC {ECO:0000313|EMBL:AKG59464.1}, 10-2-3 {ECO:0000313|EMBL:AKG59248.1},
RC 10-5-1 {ECO:0000313|EMBL:AKG61196.1}, 10-6-1
RC {ECO:0000313|EMBL:AKG60837.1}, 10-6-3 {ECO:0000313|EMBL:AKG59974.1},
RC 11M {ECO:0000313|EMBL:AKG60694.1}, 12-12-2
RC {ECO:0000313|EMBL:AKG60980.1}, 2-4-2 {ECO:0000313|EMBL:AKG60263.1},
RC 2-5-3 {ECO:0000313|EMBL:AKG60548.1}, 31XL
RC {ECO:0000313|EMBL:AKG61413.1}, 36L {ECO:0000313|EMBL:AKG59611.1}, 3M
RC {ECO:0000313|EMBL:AKG59828.1}, 47M {ECO:0000313|EMBL:AKG61486.1},
RC 5-2-1 {ECO:0000313|EMBL:AKG60048.1}, 5-4-2
RC {ECO:0000313|EMBL:AKG61922.1}, 5-5-2 {ECO:0000313|EMBL:AKG60765.1},
RC 57M {ECO:0000313|EMBL:AKG59393.1}, 66S {ECO:0000313|EMBL:AKG59757.1},
RC and 76M {ECO:0000313|EMBL:AKG61125.1};
RX PubMed=25926637; DOI=10.1128/JVI.00880-15;
RA Lee K., Kolb A.W., Sverchkov Y., Cuellar J.A., Craven M., Brandt C.R.;
RT "Recombination Analysis of Herpes Simplex Virus 1 Reveals a Bias toward GC
RT Content and the Inverted Repeat Regions.";
RL J. Virol. 89:7214-7223(2015).
RN [4] {ECO:0000313|EMBL:ANN83966.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=20-14-18 {ECO:0000313|EMBL:ANN84579.1}, 20-14-22
RC {ECO:0000313|EMBL:ANN85266.1}, 20-14-23 {ECO:0000313|EMBL:ANN85650.1},
RC 914-B2 {ECO:0000313|EMBL:ANN84196.1}, 914-D2
RC {ECO:0000313|EMBL:ANN84273.1}, 914-N3 {ECO:0000313|EMBL:ANN84502.1},
RC 914-O2 {ECO:0000313|EMBL:ANN83966.1}, 914-Y2
RC {ECO:0000313|EMBL:ANN84961.1}, 914-Z {ECO:0000313|EMBL:ANN85038.1},
RC and IV-2 {ECO:0000313|EMBL:ANN84043.1};
RA Lee K., Kolb A., Larsen I.V., Craven M., Brandt C.R.;
RT "Mapping Murine Corneal Neovascularization and Weight Loss Virulence
RT Determinants in the HSV-1 Genome and the Detection of an Epistatic
RT Interaction between the UL and IRS/US Regions.";
RL J. Virol. 0:0-0(2016).
RN [5] {ECO:0000313|EMBL:AER38072.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OD4 {ECO:0000313|EMBL:AER38072.1};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004251}. Host cell junction
CC {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein E family.
CC {ECO:0000256|ARBA:ARBA00008101}.
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DR EMBL; JN420342; AER38072.1; -; Genomic_DNA.
DR EMBL; KR011274; AKG59248.1; -; Genomic_DNA.
DR EMBL; KR011276; AKG59393.1; -; Genomic_DNA.
DR EMBL; KR011277; AKG59464.1; -; Genomic_DNA.
DR EMBL; KR011279; AKG59611.1; -; Genomic_DNA.
DR EMBL; KR011281; AKG59757.1; -; Genomic_DNA.
DR EMBL; KR011282; AKG59828.1; -; Genomic_DNA.
DR EMBL; KR011284; AKG59974.1; -; Genomic_DNA.
DR EMBL; KR011285; AKG60048.1; -; Genomic_DNA.
DR EMBL; KR011288; AKG60263.1; -; Genomic_DNA.
DR EMBL; KR011292; AKG60548.1; -; Genomic_DNA.
DR EMBL; KR011294; AKG60694.1; -; Genomic_DNA.
DR EMBL; KR011295; AKG60765.1; -; Genomic_DNA.
DR EMBL; KR011296; AKG60837.1; -; Genomic_DNA.
DR EMBL; KR011298; AKG60980.1; -; Genomic_DNA.
DR EMBL; KR011300; AKG61125.1; -; Genomic_DNA.
DR EMBL; KR011301; AKG61196.1; -; Genomic_DNA.
DR EMBL; KR011302; AKG61269.1; -; Genomic_DNA.
DR EMBL; KR011304; AKG61413.1; -; Genomic_DNA.
DR EMBL; KR011305; AKG61486.1; -; Genomic_DNA.
DR EMBL; KR011311; AKG61922.1; -; Genomic_DNA.
DR EMBL; KR052508; AKH80538.1; -; Genomic_DNA.
DR EMBL; KX265022; ANN83966.1; -; Genomic_DNA.
DR EMBL; KX265023; ANN84043.1; -; Genomic_DNA.
DR EMBL; KX265025; ANN84196.1; -; Genomic_DNA.
DR EMBL; KX265026; ANN84273.1; -; Genomic_DNA.
DR EMBL; KX265029; ANN84502.1; -; Genomic_DNA.
DR EMBL; KX265030; ANN84579.1; -; Genomic_DNA.
DR EMBL; KX265035; ANN84961.1; -; Genomic_DNA.
DR EMBL; KX265036; ANN85038.1; -; Genomic_DNA.
DR EMBL; KX265039; ANN85266.1; -; Genomic_DNA.
DR EMBL; KX265044; ANN85650.1; -; Genomic_DNA.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR046463; Herpes_gE_N.
DR InterPro; IPR003404; Herpes_glycopE_Fc.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02480; Herpes_gE; 1.
DR Pfam; PF20418; Herpes_gE_N; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 3: Inferred from homology;
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879,
KW ECO:0000313|EMBL:AER38072.1}; Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 420..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..163
FT /note="Envelope glycoprotein E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20418"
FT DOMAIN 220..392
FT /note="Envelope glycoprotein E Fc-binding"
FT /evidence="ECO:0000259|Pfam:PF02480"
FT REGION 162..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 59049 MW; 35E22C2A38D25C16 CRC64;
MDRGAVVGFL LGVCVVSCLA GTPKTSWRRV SVGEDVSLLP APGPTGRGPT QKLLWAVEPL
DGCGPLHPSW VSLMPPKQVP ETVVDAACMR APVPLAMAYA PPAPSATGGL PTDFVWQERA
AVVNRSLVIH GVRETDSGLY TLSVGDIKDP ARQVASVVLV VQPAPVPTPP PTPADYDEDD
NDEGEDESLA GTPASGTPRL PPPPAPPRSW PSAPEVSHVR GVTVRMETPE AILFSPGETF
STNVSIHAIA HDDQTYSMDV VWLRFDVPTS CAEMRIYESC LYHPQLPECL SPADAPCAAS
TWTSRLAVRS YAGCSRTNPP PRCSAEAHME PVPGLAWQAA SVNLEFRDAS PQHSGLYLCV
VYVNDHIHAW GHITISTAAQ YRNAVVEQPL PQRGADLAEP THPHVGAPPH APPTHGALRL
GAVMGAALLL SALGLSVWAC MTCWRRRAWR AVKSRASGKG PTYIRVADSE LYADWSSDSE
GERDQVPWLA PPERPDSPST NGSGFEILSP TAPSIYPRSD GHQSRRQLTT FGSGRPDRRY
SQASDSSVFW
//
