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Database: UniProt
Entry: G8HEK1_9HIV1
LinkDB: G8HEK1_9HIV1
Original site: G8HEK1_9HIV1 
ID   G8HEK1_9HIV1            Unreviewed;       469 AA.
AC   G8HEK1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   08-NOV-2023, entry version 49.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE   AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AEQ76347.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AEQ76347.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AEQ76347.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=4059_C_6 {ECO:0000313|EMBL:AEQ76347.1};
RA   Schnell G., Joseph S., Spudich S., Price R.W., Swanstrom R.;
RT   "HIV-1 Replication in the Central Nervous System Occurs in Two Distinct
RT   Cell Types.";
RL   PLoS Pathog. 7:e1002286-e1002286(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; JN563163; AEQ76347.1; -; Genomic_RNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:AEQ76347.1};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   TRANSMEM        390..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..389
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          408..467
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ76347.1"
FT   NON_TER         469
FT                   /evidence="ECO:0000313|EMBL:AEQ76347.1"
SQ   SEQUENCE   469 AA;  51942 MW;  DABCE77B29E15147 CRC64;
     CVPLNCTKVN KTNPNTTNNG GVGMMNEEIK NCSFNVTTNE GNKVKKEYAL LYKLDVVSID
     GSSSKNETYS NYRLISCNTS VITQACPKVS FEPIPIHYCA PAGFAILKCN DKKFNGKGEC
     KNVSTVQCTH GIRPVVSTHL LLNGSLAEEE VVIRSDNFSN NAKTIIVQLN KTVKINCTRP
     NNNTRRSISF GPGRAWYATT DIVGDIRQAH CNISTTEWNN TLRLVVNKLQ EQYGTNKTIR
     FEQPVQGGDL EIVMHSFNCG GEFFYCNTSK LFNSIWNNAS TWNDTEGNGT LTLPCKIRQI
     INMWQKVGKA MYAPPISGRI NCLSNITGLL LMRDGGSNDT NEPEIFRPGG GDMRDNWRSE
     LYKYKVIKIE PLGIAPTKAK RRVVQKEKRA VGLGAMFLGF LGAAGSTMGA ASLTLTVQAR
     QLLSGIVQQQ SKLLRAIEAQ QHLLQLTVWG IKQLQARVLA VEAYLKDQQ
//
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