ID G8HVH1_BUFBU Unreviewed; 233 AA.
AC G8HVH1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AEQ75625.1};
OS Bufo bufo (European toad) (Rana bufo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo.
OX NCBI_TaxID=8384 {ECO:0000313|EMBL:AEQ75625.1};
RN [1] {ECO:0000313|EMBL:AEQ75625.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BbufoBB02 {ECO:0000313|EMBL:AEQ75605.1}, BbufoBB04
RC {ECO:0000313|EMBL:AEQ75606.1}, BbufoBB08
RC {ECO:0000313|EMBL:AEQ75607.1}, BbufoBB107
RC {ECO:0000313|EMBL:AEQ75618.1}, BbufoBB114
RC {ECO:0000313|EMBL:AEQ75619.1}, BbufoBB128
RC {ECO:0000313|EMBL:AEQ75604.1}, BbufoBB141
RC {ECO:0000313|EMBL:AEQ75620.1}, BbufoBB17
RC {ECO:0000313|EMBL:AEQ75621.1}, BbufoBB36
RC {ECO:0000313|EMBL:AEQ75623.1}, BbufoBB46
RC {ECO:0000313|EMBL:AEQ75624.1}, BbufoBB55
RC {ECO:0000313|EMBL:AEQ75625.1}, BbufoBB70
RC {ECO:0000313|EMBL:AEQ75626.1}, BbufoBB77
RC {ECO:0000313|EMBL:AEQ75627.1}, BbufoBB80
RC {ECO:0000313|EMBL:AEQ75628.1}, BbufoJV1 {ECO:0000313|EMBL:AEQ75629.1},
RC BbufoJV3 {ECO:0000313|EMBL:AEQ75622.1}, BbufoOGAM2
RC {ECO:0000313|EMBL:AEQ75608.1}, BbufoOGAM22
RC {ECO:0000313|EMBL:AEQ75609.1}, BbufoOGHI2
RC {ECO:0000313|EMBL:AEQ75610.1}, BbufoOMON1
RC {ECO:0000313|EMBL:AEQ75611.1}, BbufoOMON4
RC {ECO:0000313|EMBL:AEQ75612.1}, BbufoOMON5
RC {ECO:0000313|EMBL:AEQ75613.1}, BbufoORAG3
RC {ECO:0000313|EMBL:AEQ75614.1}, BbufoORAG5
RC {ECO:0000313|EMBL:AEQ75615.1}, BbufoORAG8
RC {ECO:0000313|EMBL:AEQ75616.1}, BbufoORAG9
RC {ECO:0000313|EMBL:AEQ75617.1}, BspinBB119
RC {ECO:0000313|EMBL:AEQ75634.1}, BspinBB12
RC {ECO:0000313|EMBL:AEQ75635.1}, BspinBB120
RC {ECO:0000313|EMBL:AEQ75636.1}, BspinBB121
RC {ECO:0000313|EMBL:AEQ75637.1}, and BspinBB13
RC {ECO:0000313|EMBL:AEQ75638.1};
RX PubMed=21964513; DOI=10.1016/j.ympev.2011.09.008;
RA Recuero E., Canestrelli D., Voros J., Szabo K., Poyarkov N.A.,
RA Arntzen J.W., Crnobrnja-Isailovic J., Kidov A.A., Cogalniceanu D.,
RA Caputo F.P., Nascetti G., Martinez-Solano I.;
RT "Multilocus species tree analyses resolve the radiation of the widespread
RT Bufo bufo species group (Anura, Bufonidae).";
RL Mol. Phylogenet. Evol. 62:71-86(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JN646963; AEQ75604.1; -; Genomic_DNA.
DR EMBL; JN646964; AEQ75605.1; -; Genomic_DNA.
DR EMBL; JN646965; AEQ75606.1; -; Genomic_DNA.
DR EMBL; JN646966; AEQ75607.1; -; Genomic_DNA.
DR EMBL; JN646967; AEQ75608.1; -; Genomic_DNA.
DR EMBL; JN646968; AEQ75609.1; -; Genomic_DNA.
DR EMBL; JN646969; AEQ75610.1; -; Genomic_DNA.
DR EMBL; JN646970; AEQ75611.1; -; Genomic_DNA.
DR EMBL; JN646971; AEQ75612.1; -; Genomic_DNA.
DR EMBL; JN646972; AEQ75613.1; -; Genomic_DNA.
DR EMBL; JN646973; AEQ75614.1; -; Genomic_DNA.
DR EMBL; JN646974; AEQ75615.1; -; Genomic_DNA.
DR EMBL; JN646975; AEQ75616.1; -; Genomic_DNA.
DR EMBL; JN646976; AEQ75617.1; -; Genomic_DNA.
DR EMBL; JN646977; AEQ75618.1; -; Genomic_DNA.
DR EMBL; JN646978; AEQ75619.1; -; Genomic_DNA.
DR EMBL; JN646979; AEQ75620.1; -; Genomic_DNA.
DR EMBL; JN646980; AEQ75621.1; -; Genomic_DNA.
DR EMBL; JN646981; AEQ75622.1; -; Genomic_DNA.
DR EMBL; JN646982; AEQ75623.1; -; Genomic_DNA.
DR EMBL; JN646983; AEQ75624.1; -; Genomic_DNA.
DR EMBL; JN646984; AEQ75625.1; -; Genomic_DNA.
DR EMBL; JN646985; AEQ75626.1; -; Genomic_DNA.
DR EMBL; JN646986; AEQ75627.1; -; Genomic_DNA.
DR EMBL; JN646987; AEQ75628.1; -; Genomic_DNA.
DR EMBL; JN646988; AEQ75629.1; -; Genomic_DNA.
DR EMBL; JN646993; AEQ75634.1; -; Genomic_DNA.
DR EMBL; JN646994; AEQ75635.1; -; Genomic_DNA.
DR EMBL; JN646995; AEQ75636.1; -; Genomic_DNA.
DR EMBL; JN646996; AEQ75637.1; -; Genomic_DNA.
DR EMBL; JN646997; AEQ75638.1; -; Genomic_DNA.
DR AlphaFoldDB; G8HVH1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 125..232
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 133..200
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 178..229
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 188..231
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEQ75625.1"
FT NON_TER 233
FT /evidence="ECO:0000313|EMBL:AEQ75625.1"
SQ SEQUENCE 233 AA; 26250 MW; 67FA2C1CE6D6CC24 CRC64;
ISYFSCMKAA PMKEASVRGQ SGLAYPGLRT HGTLESIGGP MGSSRGGGLP SLTDTFEHVI
EELLEEEQNL RQSEENKDSD MYSSRVMLST QVPLEPPLLF LLEEYKNYLD AANMSMRVRR
HSDPARRGEL SVCDSISEWV TAADKKTAID MAGQTVTVLE KVPVPKGQLK QYFYETKCNP
MGYMKEGCRG IDKRYWNSQC RTTQSYVRAL TMDSKKKVGW RFIRIDTSCV CTL
//
