ID G8HY40_9NEOB Unreviewed; 207 AA.
AC G8HY40;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AET42038.1};
OS Gephyromantis atsingy.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Mantellinae; Gephyromantis;
OC Phylacomantis.
OX NCBI_TaxID=980088 {ECO:0000313|EMBL:AET42038.1};
RN [1] {ECO:0000313|EMBL:AET42038.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22019930; DOI=10.1016/j.ympev.2011.09.023;
RA Kaffenberger N., Wollenberg K.C., Kohler J., Glaw F., Vieites D.R.,
RA Vences M.;
RT "Molecular phylogeny and biogeography of Malagasy frogs of the genus
RT Gephyromantis.";
RL Mol. Phylogenet. Evol. 62:555-560(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JN664282; AET42038.1; -; Genomic_DNA.
DR AlphaFoldDB; G8HY40; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 111..207
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET42038.1"
FT NON_TER 207
FT /evidence="ECO:0000313|EMBL:AET42038.1"
SQ SEQUENCE 207 AA; 23311 MW; 07F37C04B7D38359 CRC64;
SVRGQSGLAY PGLRTHGTLE NIGGPMSGSR GGGGLPSLTD TFEHVIEELL EEEQTIRQSE
ENKDSDMYSS RVMLSTQVPL EPPLLFLLEE YKNYLDAANM SMRVRRHSDP ARRGELSVCD
SISEWVTAAD KKTAVDMTGQ TVTVLEKVPV PKGQLKQYFY ETKCNPMGYM KDGCRGIDKR
YWNSQCRTTQ SYVRALTMDS KKKVGWR
//