ID G8HY69_9NEOB Unreviewed; 222 AA.
AC G8HY69;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AET42067.1};
OS Gephyromantis blanci.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Mantellinae; Gephyromantis;
OC Gephyromantis.
OX NCBI_TaxID=321740 {ECO:0000313|EMBL:AET42067.1};
RN [1] {ECO:0000313|EMBL:AET42067.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22019930; DOI=10.1016/j.ympev.2011.09.023;
RA Kaffenberger N., Wollenberg K.C., Kohler J., Glaw F., Vieites D.R.,
RA Vences M.;
RT "Molecular phylogeny and biogeography of Malagasy frogs of the genus
RT Gephyromantis.";
RL Mol. Phylogenet. Evol. 62:555-560(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JN664311; AET42067.1; -; Genomic_DNA.
DR AlphaFoldDB; G8HY69; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 126..222
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET42067.1"
FT NON_TER 222
FT /evidence="ECO:0000313|EMBL:AET42067.1"
SQ SEQUENCE 222 AA; 24982 MW; 5B103E9816654B1A CRC64;
VISYFSCMKA APMKEASVRG QSGLAYPGLR THGTLENIGG PMSGSRGGGL PSLTDTFEHV
IEELLEEEQT IRQSEENKDS DMYSSRVMLS TQVPLEPPLL FLLEEYKNYL DAANMSMRVR
RHSDPARRGE LSVCDSISEW VTAADKKTAV DMTGQTVTVL EKVPVPKGQL KQYFYETKCN
PMGYMKDGCR GIDKRYWNSQ CRTTQSYVRA LTMDGKKKVG WR
//