ID   G8HYL2_9NEOB            Unreviewed;       199 AA.
AC   G8HYL2;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE   AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
DE   Flags: Fragment;
GN   Name=Tyr {ECO:0000313|EMBL:AER61753.1};
OS   Gephyromantis decaryi.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Mantellinae; Gephyromantis;
OC   Gephyromantis.
OX   NCBI_TaxID=321741 {ECO:0000313|EMBL:AER61753.1};
RN   [1] {ECO:0000313|EMBL:AER61753.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22019930; DOI=10.1016/j.ympev.2011.09.023;
RA   Kaffenberger N., Wollenberg K.C., Kohler J., Glaw F., Vieites D.R.,
RA   Vences M.;
RT   "Molecular phylogeny and biogeography of Malagasy frogs of the genus
RT   Gephyromantis.";
RL   Mol. Phylogenet. Evol. 62:555-560(2012).
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004573}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
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DR   EMBL; JN664527; AER61753.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8HYL2; -.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          156..173
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AER61753.1"
FT   NON_TER         199
FT                   /evidence="ECO:0000313|EMBL:AER61753.1"
SQ   SEQUENCE   199 AA;  22949 MW;  50FBD462B7552E0F CRC64;
     GQASGRGACQ DVVLSNSPVG AQFPFSGIDD RENWPFVFYN RTCQCQGNFM GYNCGECRFG
     YTGPNCTERR NSIRKEIFKM TTAEKDKFIA YLNLAKRTVS PDFVISTGTY EQMNNGSNPM
     FADINVYDLF VWLHYYASRD AFVEGGGVWE NIDFAHEAPG FVPWHRFFLL LWEREIQKVA
     GDENFTIPFW DWRDAQQCD
//