ID G8J901_9HIV2 Unreviewed; 692 AA.
AC G8J901;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
OS Human immunodeficiency virus 2.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11709 {ECO:0000313|EMBL:AET74160.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AET74160.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA4401.15 {ECO:0000313|EMBL:AET74160.1};
RX PubMed=22072758; DOI=10.1128/JVI.06126-11;
RA de Silva T.I., Aasa-Chapman M., Cotten M., Hue S., Robinson J.,
RA Bibollet-Ruche F., Sarge-Njie R., Berry N., Jaye A., Aaby P., Whittle H.,
RA Rowland-Jones S., Weiss R.;
RT "Potent Autologous and Heterologous Neutralizing Antibody Responses Occur
RT in HIV-2 Infection across a Broad Range of Infection Outcomes.";
RL J. Virol. 86:930-946(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; JN863804; AET74160.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..495
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 513..684
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET74160.1"
FT NON_TER 692
FT /evidence="ECO:0000313|EMBL:AET74160.1"
SQ SEQUENCE 692 AA; 79300 MW; E8391685E386A281 CRC64;
ASIPLFCATK NRDTWGTIQC LPDNDDYQEI ALNVTEAFDA WDNTVTEQAV EDVWNLFETS
IKPCVKLTPL CVKMDCKRNT IIATINSTTT TNATTTATTT TTATAQNVTP TNTTMVNDTS
PCARKDTCSD LGEEDIVDCQ FNMTGLERDK SKRYKETWYS KDVVCEDNTS KDTNSTSRDT
TSCYMNHCNT SVITESCDKH YWDDMKFRYC TPPGFVLLRC NDTNYSGFEP NCSKVVASTC
TRMMETQTST WFGFNGTRAE NRTYIYWHSK DNRTIISLNK HYNLTMHCKR PGNKTVAPVT
LMSGLVFHSQ PLNKRPRQAW CWFGGRWKEA MQEVKETLAK HPRYKGTNDT KNITFTAPGK
GSDPEVAYMW SNCRGEFFYC NMAWFLNWVE NRTQPQHNYV PCHIKQIINT WHKVGKNVYL
PPREGELSCN STVTSIIANI DIDVNSNTTN ITFSAEVAEL YRLELGDYKL VEITPIGFAP
TSVKRYSSDH GRHKRGVFVL GFLGFLTTAS LAMGTASLTL SAQSRTLLAG IVQQQQQLLD
VVKRQQELLR LTVWGTKNLQ ARVTAIEKYL KDQAQLNSWG CAFRQVCHTT VPWVNDTLTP
DWDNMTWQEW EHKVRYLEAN ISQSLEQAQI QQEKNMYELQ KLNSWDVFGN WFDLTSWIKY
IQYGVLIIVG IVVLRIVIYV VQILCRLRKG YR
//
