ID G8JVT9_ERECY Unreviewed; 1029 AA.
AC G8JVT9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Ecym_7102 {ECO:0000313|EMBL:AET40954.1};
OS Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS NRRL Y-17582) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=931890 {ECO:0000313|EMBL:AET40954.1, ECO:0000313|Proteomes:UP000006790};
RN [1] {ECO:0000313|Proteomes:UP000006790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC {ECO:0000313|Proteomes:UP000006790};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
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DR EMBL; CP002503; AET40954.1; -; Genomic_DNA.
DR RefSeq; XP_003647771.1; XM_003647723.1.
DR AlphaFoldDB; G8JVT9; -.
DR STRING; 931890.G8JVT9; -.
DR GeneID; 11471237; -.
DR KEGG; erc:Ecym_7102; -.
DR eggNOG; KOG4269; Eukaryota.
DR HOGENOM; CLU_010436_0_0_1; -.
DR InParanoid; G8JVT9; -.
DR OrthoDB; 25690at2759; -.
DR Proteomes; UP000006790; Chromosome 7.
DR GO; GO:0005933; C:cellular bud; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13277; PH_Bem3; 1.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006790}.
FT DOMAIN 570..677
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 815..1029
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 266..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 113844 MW; 489A69329E9FD387 CRC64;
MDNDSDADNR SYSGSSTLQL LAQYDKYTME RDRSIESIEK NRFSESSRPS YDDLFKENVK
LKLQLKETHL EIESLKSIIA HFQDSGRFEA TKLEQRERSE PSALIRDLAL PPRSADRKRN
TKNLTLGTSS PLFADHFSSA LSGVALKELS NSSRLSASSS VLAPRSADIL VSRSSPIEEK
QLLSPMKAVS RSSSTYSTVL GSPATSVLYK TSRISINSPA KSSATSKAAS TLSLPDNINF
ENEGNQLSPQ KTDRVTQLIK SELQVLQRER VDKRSASRSN SPGISVDKTG SRSRKPSDLS
TGTRADLGNF KDMVDNVFNE NDQAVESSVN SSEDSINKSM DHLNTPNISI KDGENVETPL
TLNRGAASDV YTQTPFVLTT STGEKLESPA ASANTGHMAS LSSTGKLPQA ATPSADPHLM
SASVEGSTPH SNQEVRSADV PLFVQPEDLG TIKMEVISTL YHEPGNSANI LFSVIDRKSS
KEMFKFAKTI DSVIEFDMYI RSNMDSLALP PLPDKQLFAT NIPVKVDTRR ENLNDYFSSL
LYMTNLLPGP ALKLAEFIST TPVMNPVMGD YSKEGILLVR KAKTLGSAAS WRVRYCTVEG
NVMYLNEQSF VTDTIKLAYS TIELQANLPD DRYGTKNGFI INEHKKSGLS SSTKYYFCAE
TSREREQWIS VLTIMCDAPG GGNLNVSFNN RSEASSLVDQ GSASDSSYLG PIANLEVNND
INSPPKIPDG TGNICIPEDE KEVKRRRMKS FFAFKKLSNP APYSSGNDNV SIFSQDEEVN
STTTGTESTI HKSLQSMHLY SNNKVVFGAD LKTALQLSSH AYQGRYEIPS IVFRTLEFLY
KNRGIHEEGI FRLSGSSLLI KSLQEQFDRD HDVDLCNYNK NVVVSPENEN QGGIYVDVNT
VTGLLKLYLR RLPHMIFGDD AFSAFKQIVD KPGGKDTKFV AQEFKTLLFS GKIPKENISL
MYALFELLVK INDNNNINKM NLRNLCIVFS PTLNIPVNIL QPFILDFGYI FQDKALVNNG
QNVNLHIPL
//
