ID   G8JWU3_ERECY            Unreviewed;       928 AA.
AC   G8JWU3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN   OrderedLocusNames=Ecym_8021 {ECO:0000313|EMBL:AET41317.1};
OS   Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS   NRRL Y-17582) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=931890 {ECO:0000313|EMBL:AET41317.1, ECO:0000313|Proteomes:UP000006790};
RN   [1] {ECO:0000313|Proteomes:UP000006790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC   {ECO:0000313|Proteomes:UP000006790};
RX   DOI=10.1534/g3.111.000745;
RA   Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA   Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA   Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA   Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA   Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA   Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA   Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA   Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT   "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT   genome resolution following polyploidization.";
RL   G3 (Bethesda) 2:299-311(2012).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000256|PIRNR:PIRNR015947}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR   EMBL; CP002504; AET41317.1; -; Genomic_DNA.
DR   RefSeq; XP_003648134.1; XM_003648086.1.
DR   AlphaFoldDB; G8JWU3; -.
DR   STRING; 931890.G8JWU3; -.
DR   GeneID; 11472670; -.
DR   KEGG; erc:Ecym_8021; -.
DR   eggNOG; KOG2062; Eukaryota.
DR   HOGENOM; CLU_002323_0_0_1; -.
DR   InParanoid; G8JWU3; -.
DR   OMA; IMFGRQE; -.
DR   OrthoDB; 151732at2759; -.
DR   Proteomes; UP000006790; Chromosome 8.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR016642; 26S_Psome_Rpn2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR   InterPro; IPR048570; PSMD1_RPN2_N.
DR   InterPro; IPR040623; RPN2_C.
DR   PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   Pfam; PF01851; PC_rep; 4.
DR   Pfam; PF18004; RPN2_C; 1.
DR   Pfam; PF21505; RPN2_N; 1.
DR   PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006790};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          5..299
FT                   /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21505"
FT   DOMAIN          748..903
FT                   /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18004"
FT   REGION          807..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        809..827
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  102773 MW;  FCFC464321D286DB CRC64;
     MSVITAAPLL ALLRESDNTV KSYALKSIND VVDQLWSEVS NDITDIEALY EDSKFQDRKL
     AALVASKIYY NLGEYESAVK YALAAEEYFD INEKSRYVET IVSQSIELYI KLSSEKYGSN
     GEELDKQLVG IFERMLSKCV SAGEYKLALG IALESYRLDV VSRILNQQTS ETSALKLITY
     VLVAATTTVN NTYFRLNILH ELFEILIKLK SPDYFAISKI IVNLNESDLA RRLFKKLVAE
     ENFEIAYQIA FDLVTSASQG LLNDLVTSLS SESYDSKLVE ILSGIPTCDF YNTFLFQNKN
     VRLGLLNKSK LALDGKFSLF HTAVSVSNAF MHAGTTDDTF IRLNLQWLGK AQNWAKFTAT
     ASLGIIHQGN LSEGKKILEP YLPGSRSSSR YIKGGSLYGL GLIFAGYGKE IIGYLKQQIL
     ENSSNASDED VDVLLHGASL GIGLAGMGSN NTEIYEALKE VLYADSANSG AAAALGIGLT
     MLGSGDKAVL DNLFTYAQET SHGEITRGLA VALALVNYGR EELADELIKK MLHHENDFLR
     YGAVYMIALA YAGTSNNKAV KKLLHVAVSD SNCDVRRAAV TGLGFILIRD YTTVPRIVEL
     LSESHNPHVR CGTAFALGVA CAGRGLQSAY DVLEPLTNDP VDFVRQAAMI SLSMILIQQT
     EKTNPKVKEV NEQFRSVISN KHQEGLAKFG ACVAQGIMNA GGRNVTIQLE NSEMGTLNTK
     SVIGLAMFTQ FWYWFPLSHF LSLAFTPTSI IGVRSQDLAI PKFSFNCHTK EGIFDYPTRF
     EEDVDKGVEK VATAVLSTTA KAKARAKKSK KDKVLEPEKL KEDPKSEKDV KEKKEVEVIE
     EEVKIKYTSS SYKVDNMSRV LPQQLKYIVF AKEERFTPVR KFKGSNGVIV LSDKTPDEPA
     EIIKTVRQEK DVEAPLPTPF KINEELEF
//