ID G8P940_LACLC Unreviewed; 359 AA.
AC G8P940;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=DNA replication and repair protein RecF {ECO:0000256|ARBA:ARBA00020170, ECO:0000256|HAMAP-Rule:MF_00365};
GN Name=recF {ECO:0000256|HAMAP-Rule:MF_00365};
GN ORFNames=llh_11310 {ECO:0000313|EMBL:AEU41438.1};
OS Lactococcus cremoris subsp. cremoris A76.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=1104322 {ECO:0000313|EMBL:AEU41438.1, ECO:0000313|Proteomes:UP000007114};
RN [1] {ECO:0000313|EMBL:AEU41438.1, ECO:0000313|Proteomes:UP000007114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A76 {ECO:0000313|EMBL:AEU41438.1,
RC ECO:0000313|Proteomes:UP000007114};
RA Bolotin A., Quinquis B., Ehrlich S.D., Sorokin A.;
RT "Complete Genome Sequence of Lactococcus lactis subsp. cremoris A76.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC required for DNA replication and normal SOS inducibility. RecF binds
CC preferentially to single-stranded, linear DNA. It also seems to bind
CC ATP. {ECO:0000256|HAMAP-Rule:MF_00365, ECO:0000256|RuleBase:RU000578}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00365,
CC ECO:0000256|RuleBase:RU000578}.
CC -!- SIMILARITY: Belongs to the RecF family. {ECO:0000256|ARBA:ARBA00008016,
CC ECO:0000256|HAMAP-Rule:MF_00365, ECO:0000256|RuleBase:RU000578}.
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DR EMBL; CP003132; AEU41438.1; -; Genomic_DNA.
DR RefSeq; WP_011677029.1; NC_017492.1.
DR AlphaFoldDB; G8P940; -.
DR SMR; G8P940; -.
DR KEGG; llr:llh_11310; -.
DR PATRIC; fig|1104322.3.peg.2266; -.
DR HOGENOM; CLU_040267_0_1_9; -.
DR Proteomes; UP000007114; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03242; ABC_RecF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.1050.90; RecF/RecN/SMC, N-terminal domain; 1.
DR HAMAP; MF_00365; RecF; 1.
DR InterPro; IPR001238; DNA-binding_RecF.
DR InterPro; IPR018078; DNA-binding_RecF_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR042174; RecF_2.
DR NCBIfam; TIGR00611; recf; 1.
DR PANTHER; PTHR32182; DNA REPLICATION AND REPAIR PROTEIN RECF; 1.
DR PANTHER; PTHR32182:SF0; DNA REPLICATION AND REPAIR PROTEIN RECF; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00617; RECF_1; 1.
DR PROSITE; PS00618; RECF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00365};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00365};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00365}.
FT DOMAIN 3..354
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00365"
SQ SEQUENCE 359 AA; 41602 MW; 59E33DBE3F1D4CD5 CRC64;
MKLKQIELKN FRNYEDLKLD FHPNLNIFLG QNAQGKTNIL EAIHFLALTR SHRTSHDKEL
ICWSGQEMKV SGLVEKAHAT VPLEVQLSSK GRIAKANHLK ENRLADYIGQ LKILMFAPEN
LELVKGSPAT RRRFMDIELG QIHAVYLYDS MRYNRALKER NAYLKFDQAK IDKNFLTVLD
EQLAEHGNKI MFERKTFIEK LEIHAKKIHE QLTHGLETLK ITYNQNVKTD FSKELLSRQD
HDIFRHQTTV GPHRDDLQFF INEINVADFG SQGQQRTVAL SIKLAEIDLI FEETGEYPIL
LLDDVMSELD NHRQLDLIET SLGKTQTFIT TTTLDHLKNL PENLSIFHVT DGTIEKEKE
//
