ID   G8R4U5_OWEHD            Unreviewed;       723 AA.
AC   G8R4U5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   OrderedLocusNames=Oweho_2245 {ECO:0000313|EMBL:AEV33219.1};
OS   Owenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 / NRRL
OS   B-23963 / UST20020801).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Owenweeksiaceae;
OC   Owenweeksia.
OX   NCBI_TaxID=926562 {ECO:0000313|EMBL:AEV33219.1, ECO:0000313|Proteomes:UP000005631};
RN   [1] {ECO:0000313|EMBL:AEV33219.1, ECO:0000313|Proteomes:UP000005631}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 17368 / JCM 12287 / NRRL B-23963
RC   {ECO:0000313|Proteomes:UP000005631};
RX   PubMed=23450211; DOI=10.4056/sigs.3296896;
RA   Riedel T., Held B., Nolan M., Lucas S., Lapidus A., Tice H., Del Rio T.G.,
RA   Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S., Liolios K.,
RA   Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Rohde M., Tindall B.J., Detter J.C., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Genome sequence of the orange-pigmented seawater bacterium Owenweeksia
RT   hongkongensis type strain (UST20020801(T)).";
RL   Stand. Genomic Sci. 7:120-130(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
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DR   EMBL; CP003156; AEV33219.1; -; Genomic_DNA.
DR   RefSeq; WP_014202568.1; NC_016599.1.
DR   AlphaFoldDB; G8R4U5; -.
DR   STRING; 926562.Oweho_2245; -.
DR   KEGG; oho:Oweho_2245; -.
DR   PATRIC; fig|926562.3.peg.2261; -.
DR   eggNOG; COG1505; Bacteria.
DR   HOGENOM; CLU_011290_1_1_10; -.
DR   OrthoDB; 9801421at2; -.
DR   Proteomes; UP000005631; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000313|EMBL:AEV33219.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005631};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..723
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003514332"
FT   DOMAIN          33..435
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          492..707
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   723 AA;  80585 MW;  A24F3D50913C85E0 CRC64;
     MKTKKVLSVV MASSILMACN QQVEKKETAL SYPNTMRDTT VVDEYFGTKV PDPYRWLEND
     TSAETEAWVK AENKVTFDYL KEIPYRKDIN DRLTDLWNYE KYSAPFVRGE YTYFYKNDGL
     QNQSVLYRQK GEEGTPEVFL DPNKFSEDGT TSLAGLSFTE DGSMVAYQIS EGGSDWRKVI
     VLNAETKEQI EDTLIDVKFS GVSWLNNDGF YYSSYDKPKD GSALSGLTQY HKLFYHKLGT
     EQSTDELIFG GDITPRRYIG GYVTEDNNYL VISAATSTSG NELYIKDLRK ADSKIVNVVD
     NFENNNSVIH TEGDKIFIKT NLNAPNGRLV TTNIANPSPA NWKDLIAETE NVLSVGSAGG
     KFFASYMIDA TDRVYQYSLD GKMEKEIELP ALGSAGGFGG RMEDTVLYYS FTNYVYPSTI
     FKYNIADGTS EVYKKSGVKF DPANYESKQV FYTSKDGTKI PMIITHKKGL KLDGTNPTYL
     YGYGGFNVSL TPSFSTSTIV LLENGGIMAV ANLRGGGEYG EKWHTTGTKM NKQNVFDDFI
     AAAEYLISEK YTSSEKLAVA GGSNGGLLVG ATMTQRPSLM KVAFPAVGVL DMLRYNKFTA
     GAGWAYDYGT AEDSKEMFDY LYGYSPYHNL KKGTEYPATM VTTGDHDDRV VPAHSFKFAA
     ELQHCHAGNN PVLIRIETNA GHGAGKPTDK IIQEQADKWS FMFWNMGYEK LPSASENSEV
     AEK
//