ID   G8R730_OWEHD            Unreviewed;      1065 AA.
AC   G8R730;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Oweho_2425 {ECO:0000313|EMBL:AEV33395.1};
OS   Owenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 / NRRL
OS   B-23963 / UST20020801).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Owenweeksiaceae;
OC   Owenweeksia.
OX   NCBI_TaxID=926562 {ECO:0000313|EMBL:AEV33395.1, ECO:0000313|Proteomes:UP000005631};
RN   [1] {ECO:0000313|EMBL:AEV33395.1, ECO:0000313|Proteomes:UP000005631}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 17368 / JCM 12287 / NRRL B-23963
RC   {ECO:0000313|Proteomes:UP000005631};
RX   PubMed=23450211; DOI=10.4056/sigs.3296896;
RA   Riedel T., Held B., Nolan M., Lucas S., Lapidus A., Tice H., Del Rio T.G.,
RA   Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S., Liolios K.,
RA   Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Rohde M., Tindall B.J., Detter J.C., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Genome sequence of the orange-pigmented seawater bacterium Owenweeksia
RT   hongkongensis type strain (UST20020801(T)).";
RL   Stand. Genomic Sci. 7:120-130(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP003156; AEV33395.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8R730; -.
DR   STRING; 926562.Oweho_2425; -.
DR   KEGG; oho:Oweho_2425; -.
DR   PATRIC; fig|926562.3.peg.2441; -.
DR   eggNOG; COG1074; Bacteria.
DR   HOGENOM; CLU_010638_0_0_10; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000005631; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Exonuclease {ECO:0000313|EMBL:AEV33395.1};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000313|EMBL:AEV33395.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005631}.
FT   DOMAIN          6..495
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          496..761
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         27..34
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1065 AA;  121716 MW;  817A858F73B7F19C CRC64;
     MYAPNFEGRT CRREILLKLS KFKIYNASAG AGKTYTLVKE FLRICLTGEN ANQYRQILAI
     TFTNKAANEM KERIVQKLET FANEQESIQD PIFLQLAEDL QVSHVRLSYV AQAALKSILH
     NYSAFSVSTI DKFTNRLIRS FSQDLKLSSN YEVELDTDEL LREAVDRMLA DLQEGDATSK
     VLLEFINDKL SEGKSPRPEQ SLLAMGRNLF DEAAYPYLKH LKGFGKEEIM KAAGKLRKEK
     KDWEDKWSDE AQEMMTLIHS QGIERMDFSS GTVYNYILKF VEKDSSKWPI NKTLEKVVFD
     GAPFYAKTKA KNLAPRFSPI EDELRAKLDK LVKEVVEVFP RYHLITKILK DVYSLAVLAE
     IDKNLQEVKE EENKLPIGEF NKLISDKLEN EPTAYLFEKL GDRYQYFFID EFQDTSVLQW
     RNLLPLINNA LSSSGSAMIV GDAKQSIYRW RGGEVGQFID LSNDVDPSNK VLLNGEEMEL
     YSRETLNLGS NFRSRKNVVE FNNDFFTNSA DLMQEEVFKD IYSASNQNVE RQDGGYVCLK
     QIEYDKETYE QQQCEESLAV IQDAISRGYK LNDITIITRK KDYLAALAEF LLDKGIKVIS
     PDSLLLEQSQ EVRSLVSFLK FLCRPDDFAS RWDFLSSLWA LDVIKEEYKE EHQFISSHVK
     SNPVELNSAL SEIIPNYSYP ELLQQGLLDK VYLLAKWFKL DVQGNPFLHT FVDKVSDFQN
     NKKGGEAEFC RHWDDKGSRQ SIALPDGVDA VNLMTVHKSK GLEFPITIVS FADWLSTSEP
     NGSSAWVNLE SHDMAGLPVA RVSLSENANA HKDYQNLYQR NKGLVYLDNL NLAYVAFTRA
     VDELYVFGSK GKPKESSNLT IYISQYFKNK GVEDLLLEVG ERSQKRHEDV KDNALMWKNY
     EAVSWQDRLR ITIDAPLDWT SGESEGTSYG KKVHGVFAKL DGKTSIEEII DNEVILGRLS
     NEESEPLKTL IDSVLANPEV MPYFAEGVEM LNEKDILLPK KGSLRPDRLS VVDGVVHIID
     YKTGVSDPNH QKQLDAYSDV LLEMGFKVGD KVLIYLNENP EVVKW
//