ID G8S4H1_ACTS5 Unreviewed; 472 AA.
AC G8S4H1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Aldehyde dehydrogenase (NAD+) {ECO:0000313|EMBL:AEV88635.1};
DE EC=1.2.1.3 {ECO:0000313|EMBL:AEV88635.1};
GN OrderedLocusNames=ACPL_7755 {ECO:0000313|EMBL:AEV88635.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV88635.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP003170; AEV88635.1; -; Genomic_DNA.
DR RefSeq; WP_014694695.1; NZ_LT827010.1.
DR AlphaFoldDB; G8S4H1; -.
DR STRING; 134676.ACPL_7755; -.
DR KEGG; ase:ACPL_7755; -.
DR PATRIC; fig|134676.3.peg.7681; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_11; -.
DR OrthoDB; 3495787at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440}.
FT DOMAIN 33..471
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 472 AA; 50553 MW; 0845D26C8B092333 CRC64;
MFAYAPAPES RSIVSLEPSY GLFIDGEFQG SGSVFKTVNP ATEEVLAEVA MAGPEDVNRA
VAAARRAFTG WSALPGAERA KYLFRIARII QERSRELAVL ESLDNGKPIR EARDVDLPLV
AAHFFYYAGW ADKLPYAGFG ADPRPLGVAA QVVPWNFPLL MLAWKVAPAL ATGNTVVLKP
AETTPLSALF FADVCRQAEL PPGVVNIVTG AGDTGAYLVA HPDVDKVAFT GSTEVGREIA
RTVAGTGKRL TLELGGKAAN IVFDDAPIDQ AVEGIVNGIF FNQGHVCCAG SRLLVQESIF
EELLESLKRR MGTLRVGDPL DKNTDIGAIN SAAQLARISE LSEIGAQEGA ARWSPACDLP
DRGFWFPPTI FTGVTQAHRI AREEIFGPVL SVLTFRTPAE AVEKANNTPY GLSAGIWSEK
GSRILAVADK LRAGVVWANT FNKFDPASPF GGYKESGYGR EGGRHGLEAY LA
//
