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Database: UniProt
Entry: G8SJL2_ACTS5
LinkDB: G8SJL2_ACTS5
Original site: G8SJL2_ACTS5 
ID   G8SJL2_ACTS5            Unreviewed;      5216 AA.
AC   G8SJL2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AEV86939.1};
DE            EC=2.3.1.94 {ECO:0000313|EMBL:AEV86939.1};
GN   Name=pks1D {ECO:0000313|EMBL:AEV86939.1};
GN   OrderedLocusNames=ACPL_6052 {ECO:0000313|EMBL:AEV86939.1};
OS   Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV86939.1, ECO:0000313|Proteomes:UP000005440};
RN   [1] {ECO:0000313|Proteomes:UP000005440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC   {ECO:0000313|Proteomes:UP000005440};
RA   Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA   Wehmeier U.F., Stoye J., Puehler A.;
RT   "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT   SE50/110.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003170; AEV86939.1; -; Genomic_DNA.
DR   RefSeq; WP_014693009.1; NZ_LT827010.1.
DR   STRING; 134676.ACPL_6052; -.
DR   KEGG; ase:ACPL_6052; -.
DR   PATRIC; fig|134676.3.peg.5943; -.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_35_8_11; -.
DR   OMA; MHKDYSL; -.
DR   OrthoDB; 5476359at2; -.
DR   Proteomes; UP000005440; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR   CDD; cd00833; PKS; 3.
DR   Gene3D; 3.30.70.3290; -; 3.
DR   Gene3D; 3.40.47.10; -; 3.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 3.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 3.
DR   Pfam; PF21089; PKS_DH_N; 3.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF14765; PS-DH; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00826; PKS_DH; 3.
DR   SMART; SM00822; PKS_KR; 3.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR   SUPFAM; SSF53901; Thiolase-like; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00606; KS3_1; 3.
DR   PROSITE; PS52004; KS3_2; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000313|EMBL:AEV86939.1};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005440};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEV86939.1}.
FT   DOMAIN          34..443
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1573..1648
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1664..2073
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3205..3280
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3299..3716
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          4853..4928
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   5216 AA;  544243 MW;  63D37B341F63F371 CRC64;
     MPSSEEKLVE ALRASLKEAD RLRGQNRKLT AASQEPIAIV GMACRYPGGV VSPEGLWDLV
     ADGVDGVSEF PTGRGWGTDI FDPVPGAAGK SYVREGGFLH DADLFDPGFF GISPNEALVM
     DPQQRLLLEV SWEVFERAGI DPVSLRGSDT GVFVGMMYHD YAANSSTGAV ASGRLSYVLG
     LEGPSMTVDT ACSSSLVSLH LAAQALRAGE CSLAVVGGVA VMATPEVFVE FSRQRGLSPD
     GRCKSFAAGA DGTAWGEGAG VLLVERLSDA KRLGHRILAV VRGSAVNQDG ASNGLTAPNG
     PSQRRVIRKA LASARLSSAD VDVVEAHGTG TVLGDPIEAQ ALLETYGQDR ERPLLLGSIK
     SNIGHTQAAA GVASVIKMVM AMRHGVAPRT LHLDEPSPHV DWTAGNIQLL TEAEEWVVDG
     RPRRAGISSF GISGTNAHVI IEQAEEPPAA SGTDDESPIV VPLSARTPEA LADLADRLSR
     AAADLRPVDV GFTVATGRSV FEQRAAVVAG TGAELTAALS TVTASTARAG DLGVVFTGQG
     SQRLGMGREL HARFPVFAAA FDEVLAGFTA DVRKIVWGDD AEALNRTGSA QPALFAFEVA
     LFRLFESWGI RPTVLGGHSI GELAAAYVAG VWSLEDACRL VEARGRLMQA LPAGGAMVAV
     PVSADQLVLT PGVGIAALNG PASTVISGVE SEVLAIAEQF PNARRLKVSH AFHSPLMEPM
     LAEFAEIAGG VTYHQSSLPI LTSGDVTDPA FWVAHVRDAV RFTDTVAALV ERGVGTVLEI
     GPDATLTTLI GYNTDELATI AGQHRDAGET TAVATAAGRL FETGTAIDWT AFYAGRDARR
     VDLPTYPFQR RSFWLEVTEY LAESWLAQEF GGLRSTGLVA SGHPMVGAVV TAPDGPRVVL
     SGRLSLAAQP WLADHAVGGT VLVPGTGLLE LALTAGRQVD LPVVDELTLM APLLIPPADG
     VVVQVVVDDP DAAGRRAVAV YSRVEDAADD QPWTLHAQGT VSDELGGDRW DALQWPPAGA
     EPVDLTGGYP ALAEAGYGYG PAFQGLRAAW RRGDDIFAEV ATDEADADRY TLHPALLDAA
     LHAVLLTRDG DGDGRIVLPF AWSEVSVHAG TGPSSIRVRI SPAGTGDDLT IRVADQAGRA
     ILTVAALTSR PVDPAAMRAT DMDGLLHLAW DRIEAGTAAP GDHEVVMAAA FDPGTGTPVP
     ERVRAVLAGV LAKLQEGTSL AVVTRNAVAV ADGDPVDVVQ APVWGLVRSA QAENPGRFVL
     VDTDGGDVAG ALAGGAAEVA IRGNELFAPR LVRASVADSP VFTGRVLVTG GTGGLGAVVA
     RHLITGYAVR DLVLVSRRGV DAPGAAELRA DLELLGAAVN VVACDVSDRD AVAALLGEFP
     VDGIVHTAGV LDDGVLGSMT PERLDRVLAP KADAAWYLHE LAGELSAFVV FSSAAGVFGN
     PGQANYAAAN NFLDGLAQLR RALGLPAVSM AWGLWGSTGG GMGGELSPAD VARMRRGGVV
     PLTGDKGLAL FDAAAAAPVV IPMGLDLTGA DPLLVPPLLQ GLLRRRPSRT AVSAGASVWR
     SRLADLDEPG RLALMSDLVR AQAASVLGFA SADAVDAGRA FSDLGFDSLS AVEFRNALAA
     VVGIKLSPTL IFDYPTPAVL AEFLLAELTG AGEDVITSTV VADDDPIVIV GMACRYPGGV
     VSPEGLWNLV ADGVDGVTEF PTGRGWGSDV FDPNPGTPGK SYVREGGFLH DADLFDPGFF
     GISPNEALIM DPQQRLLLEV SWEVFERAGI DPVSLRGSDT GVFVGMMYHD YAANSSTGAV
     ASGRLSYVLG LEGPSMTVDT ACSSSLVSLH LAAQALRAGE CSLAVVGGVA VMATPEVFVE
     FSRQGGLSRD GRCKSFAAGA DGTAWGEGAG VLLVERLSDA KRLGHQILAV VRGSAVNQDG
     ASNGLTAPNG PSQRRVIRRA LASAGLSTAD VDVVEAHGTG TVLGDPIEAQ ALLETYGQDR
     ERPLLLGSIK SNIGHTQAAA GVAGVIKMVM AMRHGVAPRT LHLDEPSPHV DWTAGNIQLL
     TEAQEWVVDG RPRRAGISSF GISGTNAHVI IEHVDEPSVT PGADDDGPVV VPLSARTPEA
     LADLADRLGE VAASLRPVDL GFSVATSRTV FEQRAAVVAT SREGLRAGLQ AVTASVPRSG
     SLGVVFTGQG SQRLGMGREL HARFPVFAAA FDEVLAGFTV DIRQVVWGGD AATLSQTGFA
     QPALFAFEVA LFRLFESWGI RPTVLGGHSI GELAAAYVAG VWSLEDACRL VEARGRLMQA
     LPAGGAMVAL PVSADQLVLT PGVGIAALNG PTSTVISGVE SEVLAIAEQF PNARRLKVSH
     AFHSPLMEPM LAEFAEIAGG VTYHQSSLPI LTSGDVTDPA FWVAHVRDAV RFTDTVTRMI
     DHGVGTVLEI GPDATLTTLI GYNTDELATI PAQQRDTGEL LATATAAGRL FETGTAIDWT
     AFYAGRDTHR ADLPTYPFQR RSFWLEVTDY LAESWLAEEI GGLRSTGMTA SGHPMIGAVL
     SAADSTRVVL TGRLSLNSLP WLADHAVGGT VLVPGTGLLE LALTAGRHVD CPVVDELTLM
     APLLIPPADG VVVQVVVDDP DAAGRRAVSI YSQDGDRPWV RHAQGTLSAD AGAERWDVLQ
     WPPAGAEPVD LTGGYPALAD LGYGYGPVFQ GLRAAWRQGD EIFAEVAFDE VDADRYTLHP
     ALLDASLHAV LLTHDGSAGD GRIVLPFAWS TVSAFGDPGT GPKAIRVRIS PVGDSGDITV
     RVADQTGRAV LTVSALTSRP VDPAAMRAAD SAHLLEVAWQ PVEAGTAAAE DVVVLEAAAF
     DPGPGIPVPV RVRAVLDAVL ARLQEGAALA VVTRHAVAVA DGDVVDVVQS PVWGLVRAAQ
     AENPGRIVLI DSDGGDVSGA LGAGEPEVAV RGGVLSVPRL VRSSGGGGGV SFTGRVLVTG
     GTGGLGAVIA RHLVENLDVR ELLLVSRRGR DAPGAGDLKA DLEGLGATVN VVACDVSDRD
     EVAALLAAFP VDGVVHAAGV ADNGVIGSMT PERFDRVLAP KADAAWHLHE LAGDLTAFVM
     FSSAGGMVLA AGQAPYAAAN NFLDGLAHLR HARGLPAVSM AFGLWAVDAG LSAFLQEADF
     ERLRRQGLPP LTEQEGLAAF DAALTAGAAL VVPLKVDPAV PARGDDTPAL LRSLMKPASS
     RARRAGGSQV LLRQLAGLGA ADRAAALLDL VRNQVAAVLG HSSPAVVEPD RAFQELGFDS
     LSAVELRNVL NEVTGLRLPA TLVFDYPSAT AVAGYLDTQL TGAGADAAPP VTTTRRADDE
     PIAIVAMACR YPGDVTTPEE LWRLVHDGID TVSDFPDNRG WDTARIYDPE PGKFGRTYSK
     EGAFLHDAAM FDPAFFGISP NEAIAMDPQQ RLLLELAWEA AERAGIDPVT LRGSSTGVFA
     GLMYHDYGQG SDRASSSGGS LVSGRIAYTL GLEGPAVTVD TACSSSLVAL HWAVQALRSG
     ECSLALAGGV TVMSTPAMFV DFSRQRGLSP AGRCKSFAAG ADGTGWGEGA GLLLVERLSD
     ARRLGHPVLA VVKATALNQD GASNGFSAPN GPSQQRLIRQ ALSVAGLGTA DVDVVEGHGT
     GTVLGDPIEA QALLETYGRD RPDDRPLLLG SIKSNIGHTQ AAAGVAGVIK MVMAMRHGVV
     PRTLHVDQPS PHVDWTTGNI RLATETRDWP AVDRPRRAAV SSFGISGTNA HVIVEHAEDP
     APRREPVTVQ GSALVWPLSA RTPEALTALA GRLVRLLEAD PGLRAVDVGY SLGGRPVFEH
     RAAITGGYRS ELLSRARKVT PVAARPGAVG VVFTGQGSQR PGMGRELYAA FPVFAAAFDE
     VLAGFTVDIR QVVWGGDAAT LSQTGFAQPA LFAFEVALFR LFESWGIRPT VLGGHSVGEL
     AAAYVAGVWS LDDACRLVEA RGRLMQALPA GGAMVAVPVS ADQLVLTPGV GIAALNGPTS
     TVISGVEAEV LAIAEQFPNA RRLKVSHAFH SPLMEPMLAE FAEIAGGVTY NNPRFPILTS
     GDVTDPAFWV AHVRDAVRFT DTVAGLVERG VGTVLEIGPD STLSTLIGLN TAALTTVPGQ
     QRDADEADAA VAAVARLFET GTRVDWTAFY AGRGALRTEL PTYPFQRDEY WPGEQLLLTP
     DATSIGVDTM EHPLLGAAVP LADSDSFLLT GRIARQSQRW LTDHQVFDSV LLPGTGFVEI
     AVQAGEQAGC DLVEELTLIA PLVMPDSGAV LQARVSAPDE TGRRTVTVHS RAQDAAPDSR
     WTLHAEGVLG HGDGALPDDV AVWPPAGATP IDLDGGYDLL ADRGYGYGPA FQGLRAAWQL
     GDDLYAEVEL PEPVRAEAAF YGLHPALLDA TMHVLNFAGG EGAPEGQAMI PFSWSGVTLH
     ATGSTAVRVA LIRQDPASLT MRISDPAGAP VATVAGLNLR PVAVEQLRPG GRADALYRLD
     WVGRKAAGGT LPAYADIRLE PTVGDVPAAV RRNTALVLDR VQAFLADESR AGTVLAVVTR
     HAFAVADGDP VDIAHTPVWG LVRSAQAENP GRIVLVDSDG GDVSAALASG EPEIAVRGGE
     LSVPRLVRSS GGGGGVSFTG RVLVTGGTGG LGAVIARHLV EKHEISDLVL VSRRGLDAPE
     ALPLRADLQR LGATVNVVAC DVSERDEVAA LLAAFPVDGV VHAAGVADNG VIGSMTPERF
     DRVLAPKADA AWHLHELAGD LTAFVMFSSA GGMVLAAGQA PYAAANNFLD GLAHLRHARG
     LPAVSMAFGL WAVDTGLSAY LQDSDLERLR RQGLPPLTEQ EALAAFDAGL TEGHPLVAPL
     RVDQAALRSR VGDLPPLLRG LVPVTRRRAA TGAADAAKLR ARFAGLDATA QEAELRDLVL
     GFAATLLGHA DPAALDPERD FLEAGFDSLT AMDLRNHLNA ATGLDLPPMV IFDNKSPARL
     AAWLRAELAV DTTAAETGGD TLSALFRSGL EAGAVGEAYD LLRSVVRLRP RFRTVDEVGD
     LAPAVTLRES DSELPRLICL STPMATGGMH QHSRVVAHLG SPRHVVAIPT PGFVAGERLP
     ASVDVAVQAL AEQVLRAADG HPFLLLGYSS GGSLAYAVAG YLEERGIEPA GVVMLDSFRV
     EDEAAGATMP IRELTLRLYD QESLFGRFDS ARLSAMACWF DLVPQLPVRP VRAQTLFVRC
     TQSFLELEEG QRDWEAEPLG PGQTLVPLAA NHFSIIAERS DATAEVIDRW LTAHAL
//
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