ID G8SJL2_ACTS5 Unreviewed; 5216 AA.
AC G8SJL2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AEV86939.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:AEV86939.1};
GN Name=pks1D {ECO:0000313|EMBL:AEV86939.1};
GN OrderedLocusNames=ACPL_6052 {ECO:0000313|EMBL:AEV86939.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV86939.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003170; AEV86939.1; -; Genomic_DNA.
DR RefSeq; WP_014693009.1; NZ_LT827010.1.
DR STRING; 134676.ACPL_6052; -.
DR KEGG; ase:ACPL_6052; -.
DR PATRIC; fig|134676.3.peg.5943; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_8_11; -.
DR OMA; MHKDYSL; -.
DR OrthoDB; 5476359at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:AEV86939.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEV86939.1}.
FT DOMAIN 34..443
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1573..1648
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1664..2073
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3205..3280
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3299..3716
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4853..4928
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5216 AA; 544243 MW; 63D37B341F63F371 CRC64;
MPSSEEKLVE ALRASLKEAD RLRGQNRKLT AASQEPIAIV GMACRYPGGV VSPEGLWDLV
ADGVDGVSEF PTGRGWGTDI FDPVPGAAGK SYVREGGFLH DADLFDPGFF GISPNEALVM
DPQQRLLLEV SWEVFERAGI DPVSLRGSDT GVFVGMMYHD YAANSSTGAV ASGRLSYVLG
LEGPSMTVDT ACSSSLVSLH LAAQALRAGE CSLAVVGGVA VMATPEVFVE FSRQRGLSPD
GRCKSFAAGA DGTAWGEGAG VLLVERLSDA KRLGHRILAV VRGSAVNQDG ASNGLTAPNG
PSQRRVIRKA LASARLSSAD VDVVEAHGTG TVLGDPIEAQ ALLETYGQDR ERPLLLGSIK
SNIGHTQAAA GVASVIKMVM AMRHGVAPRT LHLDEPSPHV DWTAGNIQLL TEAEEWVVDG
RPRRAGISSF GISGTNAHVI IEQAEEPPAA SGTDDESPIV VPLSARTPEA LADLADRLSR
AAADLRPVDV GFTVATGRSV FEQRAAVVAG TGAELTAALS TVTASTARAG DLGVVFTGQG
SQRLGMGREL HARFPVFAAA FDEVLAGFTA DVRKIVWGDD AEALNRTGSA QPALFAFEVA
LFRLFESWGI RPTVLGGHSI GELAAAYVAG VWSLEDACRL VEARGRLMQA LPAGGAMVAV
PVSADQLVLT PGVGIAALNG PASTVISGVE SEVLAIAEQF PNARRLKVSH AFHSPLMEPM
LAEFAEIAGG VTYHQSSLPI LTSGDVTDPA FWVAHVRDAV RFTDTVAALV ERGVGTVLEI
GPDATLTTLI GYNTDELATI AGQHRDAGET TAVATAAGRL FETGTAIDWT AFYAGRDARR
VDLPTYPFQR RSFWLEVTEY LAESWLAQEF GGLRSTGLVA SGHPMVGAVV TAPDGPRVVL
SGRLSLAAQP WLADHAVGGT VLVPGTGLLE LALTAGRQVD LPVVDELTLM APLLIPPADG
VVVQVVVDDP DAAGRRAVAV YSRVEDAADD QPWTLHAQGT VSDELGGDRW DALQWPPAGA
EPVDLTGGYP ALAEAGYGYG PAFQGLRAAW RRGDDIFAEV ATDEADADRY TLHPALLDAA
LHAVLLTRDG DGDGRIVLPF AWSEVSVHAG TGPSSIRVRI SPAGTGDDLT IRVADQAGRA
ILTVAALTSR PVDPAAMRAT DMDGLLHLAW DRIEAGTAAP GDHEVVMAAA FDPGTGTPVP
ERVRAVLAGV LAKLQEGTSL AVVTRNAVAV ADGDPVDVVQ APVWGLVRSA QAENPGRFVL
VDTDGGDVAG ALAGGAAEVA IRGNELFAPR LVRASVADSP VFTGRVLVTG GTGGLGAVVA
RHLITGYAVR DLVLVSRRGV DAPGAAELRA DLELLGAAVN VVACDVSDRD AVAALLGEFP
VDGIVHTAGV LDDGVLGSMT PERLDRVLAP KADAAWYLHE LAGELSAFVV FSSAAGVFGN
PGQANYAAAN NFLDGLAQLR RALGLPAVSM AWGLWGSTGG GMGGELSPAD VARMRRGGVV
PLTGDKGLAL FDAAAAAPVV IPMGLDLTGA DPLLVPPLLQ GLLRRRPSRT AVSAGASVWR
SRLADLDEPG RLALMSDLVR AQAASVLGFA SADAVDAGRA FSDLGFDSLS AVEFRNALAA
VVGIKLSPTL IFDYPTPAVL AEFLLAELTG AGEDVITSTV VADDDPIVIV GMACRYPGGV
VSPEGLWNLV ADGVDGVTEF PTGRGWGSDV FDPNPGTPGK SYVREGGFLH DADLFDPGFF
GISPNEALIM DPQQRLLLEV SWEVFERAGI DPVSLRGSDT GVFVGMMYHD YAANSSTGAV
ASGRLSYVLG LEGPSMTVDT ACSSSLVSLH LAAQALRAGE CSLAVVGGVA VMATPEVFVE
FSRQGGLSRD GRCKSFAAGA DGTAWGEGAG VLLVERLSDA KRLGHQILAV VRGSAVNQDG
ASNGLTAPNG PSQRRVIRRA LASAGLSTAD VDVVEAHGTG TVLGDPIEAQ ALLETYGQDR
ERPLLLGSIK SNIGHTQAAA GVAGVIKMVM AMRHGVAPRT LHLDEPSPHV DWTAGNIQLL
TEAQEWVVDG RPRRAGISSF GISGTNAHVI IEHVDEPSVT PGADDDGPVV VPLSARTPEA
LADLADRLGE VAASLRPVDL GFSVATSRTV FEQRAAVVAT SREGLRAGLQ AVTASVPRSG
SLGVVFTGQG SQRLGMGREL HARFPVFAAA FDEVLAGFTV DIRQVVWGGD AATLSQTGFA
QPALFAFEVA LFRLFESWGI RPTVLGGHSI GELAAAYVAG VWSLEDACRL VEARGRLMQA
LPAGGAMVAL PVSADQLVLT PGVGIAALNG PTSTVISGVE SEVLAIAEQF PNARRLKVSH
AFHSPLMEPM LAEFAEIAGG VTYHQSSLPI LTSGDVTDPA FWVAHVRDAV RFTDTVTRMI
DHGVGTVLEI GPDATLTTLI GYNTDELATI PAQQRDTGEL LATATAAGRL FETGTAIDWT
AFYAGRDTHR ADLPTYPFQR RSFWLEVTDY LAESWLAEEI GGLRSTGMTA SGHPMIGAVL
SAADSTRVVL TGRLSLNSLP WLADHAVGGT VLVPGTGLLE LALTAGRHVD CPVVDELTLM
APLLIPPADG VVVQVVVDDP DAAGRRAVSI YSQDGDRPWV RHAQGTLSAD AGAERWDVLQ
WPPAGAEPVD LTGGYPALAD LGYGYGPVFQ GLRAAWRQGD EIFAEVAFDE VDADRYTLHP
ALLDASLHAV LLTHDGSAGD GRIVLPFAWS TVSAFGDPGT GPKAIRVRIS PVGDSGDITV
RVADQTGRAV LTVSALTSRP VDPAAMRAAD SAHLLEVAWQ PVEAGTAAAE DVVVLEAAAF
DPGPGIPVPV RVRAVLDAVL ARLQEGAALA VVTRHAVAVA DGDVVDVVQS PVWGLVRAAQ
AENPGRIVLI DSDGGDVSGA LGAGEPEVAV RGGVLSVPRL VRSSGGGGGV SFTGRVLVTG
GTGGLGAVIA RHLVENLDVR ELLLVSRRGR DAPGAGDLKA DLEGLGATVN VVACDVSDRD
EVAALLAAFP VDGVVHAAGV ADNGVIGSMT PERFDRVLAP KADAAWHLHE LAGDLTAFVM
FSSAGGMVLA AGQAPYAAAN NFLDGLAHLR HARGLPAVSM AFGLWAVDAG LSAFLQEADF
ERLRRQGLPP LTEQEGLAAF DAALTAGAAL VVPLKVDPAV PARGDDTPAL LRSLMKPASS
RARRAGGSQV LLRQLAGLGA ADRAAALLDL VRNQVAAVLG HSSPAVVEPD RAFQELGFDS
LSAVELRNVL NEVTGLRLPA TLVFDYPSAT AVAGYLDTQL TGAGADAAPP VTTTRRADDE
PIAIVAMACR YPGDVTTPEE LWRLVHDGID TVSDFPDNRG WDTARIYDPE PGKFGRTYSK
EGAFLHDAAM FDPAFFGISP NEAIAMDPQQ RLLLELAWEA AERAGIDPVT LRGSSTGVFA
GLMYHDYGQG SDRASSSGGS LVSGRIAYTL GLEGPAVTVD TACSSSLVAL HWAVQALRSG
ECSLALAGGV TVMSTPAMFV DFSRQRGLSP AGRCKSFAAG ADGTGWGEGA GLLLVERLSD
ARRLGHPVLA VVKATALNQD GASNGFSAPN GPSQQRLIRQ ALSVAGLGTA DVDVVEGHGT
GTVLGDPIEA QALLETYGRD RPDDRPLLLG SIKSNIGHTQ AAAGVAGVIK MVMAMRHGVV
PRTLHVDQPS PHVDWTTGNI RLATETRDWP AVDRPRRAAV SSFGISGTNA HVIVEHAEDP
APRREPVTVQ GSALVWPLSA RTPEALTALA GRLVRLLEAD PGLRAVDVGY SLGGRPVFEH
RAAITGGYRS ELLSRARKVT PVAARPGAVG VVFTGQGSQR PGMGRELYAA FPVFAAAFDE
VLAGFTVDIR QVVWGGDAAT LSQTGFAQPA LFAFEVALFR LFESWGIRPT VLGGHSVGEL
AAAYVAGVWS LDDACRLVEA RGRLMQALPA GGAMVAVPVS ADQLVLTPGV GIAALNGPTS
TVISGVEAEV LAIAEQFPNA RRLKVSHAFH SPLMEPMLAE FAEIAGGVTY NNPRFPILTS
GDVTDPAFWV AHVRDAVRFT DTVAGLVERG VGTVLEIGPD STLSTLIGLN TAALTTVPGQ
QRDADEADAA VAAVARLFET GTRVDWTAFY AGRGALRTEL PTYPFQRDEY WPGEQLLLTP
DATSIGVDTM EHPLLGAAVP LADSDSFLLT GRIARQSQRW LTDHQVFDSV LLPGTGFVEI
AVQAGEQAGC DLVEELTLIA PLVMPDSGAV LQARVSAPDE TGRRTVTVHS RAQDAAPDSR
WTLHAEGVLG HGDGALPDDV AVWPPAGATP IDLDGGYDLL ADRGYGYGPA FQGLRAAWQL
GDDLYAEVEL PEPVRAEAAF YGLHPALLDA TMHVLNFAGG EGAPEGQAMI PFSWSGVTLH
ATGSTAVRVA LIRQDPASLT MRISDPAGAP VATVAGLNLR PVAVEQLRPG GRADALYRLD
WVGRKAAGGT LPAYADIRLE PTVGDVPAAV RRNTALVLDR VQAFLADESR AGTVLAVVTR
HAFAVADGDP VDIAHTPVWG LVRSAQAENP GRIVLVDSDG GDVSAALASG EPEIAVRGGE
LSVPRLVRSS GGGGGVSFTG RVLVTGGTGG LGAVIARHLV EKHEISDLVL VSRRGLDAPE
ALPLRADLQR LGATVNVVAC DVSERDEVAA LLAAFPVDGV VHAAGVADNG VIGSMTPERF
DRVLAPKADA AWHLHELAGD LTAFVMFSSA GGMVLAAGQA PYAAANNFLD GLAHLRHARG
LPAVSMAFGL WAVDTGLSAY LQDSDLERLR RQGLPPLTEQ EALAAFDAGL TEGHPLVAPL
RVDQAALRSR VGDLPPLLRG LVPVTRRRAA TGAADAAKLR ARFAGLDATA QEAELRDLVL
GFAATLLGHA DPAALDPERD FLEAGFDSLT AMDLRNHLNA ATGLDLPPMV IFDNKSPARL
AAWLRAELAV DTTAAETGGD TLSALFRSGL EAGAVGEAYD LLRSVVRLRP RFRTVDEVGD
LAPAVTLRES DSELPRLICL STPMATGGMH QHSRVVAHLG SPRHVVAIPT PGFVAGERLP
ASVDVAVQAL AEQVLRAADG HPFLLLGYSS GGSLAYAVAG YLEERGIEPA GVVMLDSFRV
EDEAAGATMP IRELTLRLYD QESLFGRFDS ARLSAMACWF DLVPQLPVRP VRAQTLFVRC
TQSFLELEEG QRDWEAEPLG PGQTLVPLAA NHFSIIAERS DATAEVIDRW LTAHAL
//