ID G8SKT9_ACTS5 Unreviewed; 304 AA.
AC G8SKT9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Proline iminopeptidase {ECO:0000313|EMBL:AEV86964.1};
DE EC=3.4.11.5 {ECO:0000313|EMBL:AEV86964.1};
GN Name=pip2 {ECO:0000313|EMBL:AEV86964.1};
GN OrderedLocusNames=ACPL_6077 {ECO:0000313|EMBL:AEV86964.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV86964.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S33 family.
CC {ECO:0000256|ARBA:ARBA00010088, ECO:0000256|PIRNR:PIRNR005539}.
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DR EMBL; CP003170; AEV86964.1; -; Genomic_DNA.
DR AlphaFoldDB; G8SKT9; -.
DR STRING; 134676.ACPL_6077; -.
DR KEGG; ase:ACPL_6077; -.
DR PATRIC; fig|134676.3.peg.5966; -.
DR eggNOG; COG0596; Bacteria.
DR HOGENOM; CLU_020336_15_1_11; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR002410; Peptidase_S33.
DR InterPro; IPR005945; Pro_imino_pep.
DR NCBIfam; TIGR01250; pro_imino_pep_2; 1.
DR PANTHER; PTHR43194; HYDROLASE ALPHA/BETA FOLD FAMILY; 1.
DR PANTHER; PTHR43194:SF5; PIMELOYL-[ACYL-CARRIER PROTEIN] METHYL ESTER ESTERASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF005539; Pept_S33_TRI_F1; 1.
DR PRINTS; PR00793; PROAMNOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:AEV86964.1};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR005539, ECO:0000313|EMBL:AEV86964.1};
KW Protease {ECO:0000313|EMBL:AEV86964.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440}.
FT DOMAIN 28..281
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 107
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
FT ACT_SITE 247
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
FT ACT_SITE 274
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
SQ SEQUENCE 304 AA; 33701 MW; 4899ADB4B81B2F3B CRC64;
MPTAKGTVAF GPHRTWYRVT GQLGAGRPAL VVLHGGPGIT HDYLKNIADL AADGWPVVHY
DQLGNGGSTH LPERGADFWT PALFLAELDN LLTGLGIADD YVLLGHSWGG MLGAAHAATR
PAGLRGLIVA NSPASYPLWL QEMKVLRDRL PDGVNDTLLR HEAAGTVDDP EYLAASRAFY
ERHVCRRVPW PSDYMASFYE LYNDPTVYRT MNGPTEFHVI GTLRDWSVID LLPSVAVPTL
VISGRHDEAT PATLQPYLDL VPDVRWELFE ESSHTPNLEE PDRFREVLGA FLSELTRSPR
WQQD
//
