ID G8UII0_TANFA Unreviewed; 655 AA.
AC G8UII0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Neutral metalloproteinase {ECO:0000256|RuleBase:RU366073};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU366073};
GN OrderedLocusNames=BFO_1168 {ECO:0000313|EMBL:AEW20287.1};
OS Tannerella forsythia (strain ATCC 43037 / JCM 10827 / CCUG 21028 A / KCTC
OS 5666 / FDC 338) (Bacteroides forsythus).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Tannerella.
OX NCBI_TaxID=203275 {ECO:0000313|EMBL:AEW20287.1, ECO:0000313|Proteomes:UP000005436};
RN [1] {ECO:0000313|Proteomes:UP000005436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43037 / JCM 10827 / CCUG 33226 / KCTC 5666 / FDC 338
RC {ECO:0000313|Proteomes:UP000005436};
RA Dewhirst F., Tanner A., Izard J., Brinkac L., Durkin A.S., Hostetler J.,
RA Shetty J., Torralba M., Gill S., Nelson K.;
RT "Complete sequence of Tannerella forsythia ATCC 43037.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Extracellular zinc metalloprotease.
CC {ECO:0000256|RuleBase:RU366073}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU366073};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU366073}.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388, ECO:0000256|RuleBase:RU366073}.
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DR EMBL; CP003191; AEW20287.1; -; Genomic_DNA.
DR RefSeq; WP_014224577.1; NC_016610.1.
DR AlphaFoldDB; G8UII0; -.
DR GeneID; 34758407; -.
DR KEGG; tfo:BFO_1168; -.
DR PATRIC; fig|203275.8.peg.1047; -.
DR eggNOG; COG3227; Bacteria.
DR HOGENOM; CLU_418514_0_0_10; -.
DR Proteomes; UP000005436; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR InterPro; IPR026444; Secre_tail.
DR NCBIfam; TIGR04183; Por_Secre_tail; 1.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR Pfam; PF18962; Por_Secre_tail; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366073};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU366073};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU366073};
KW Reference proteome {ECO:0000313|Proteomes:UP000005436};
KW Secreted {ECO:0000256|RuleBase:RU366073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366073}.
FT DOMAIN 57..204
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 218..374
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT DOMAIN 574..653
FT /note="Secretion system C-terminal sorting"
FT /evidence="ECO:0000259|Pfam:PF18962"
SQ SEQUENCE 655 AA; 73752 MW; 5B4D892B38EFEFD9 CRC64;
MIIKEILEKT DTLPALVYRV YLYADYPQNT EVGFIDAHTG SLRMTEPVFI DFSAQGTFAT
RYSGSQQGTT HNYQGSYHLV DSTRNTIIHT WNLEGRTNIL SRVDITDNDN NWTQAEHRPN
NNDMGLDVQW ALQRICDRLY NTHNINSMDD DGFTIDAHIR YSNNYDNAFW NSIDRTLSFG
EGGSDFQPLA SVDVVAHEFG HGITHFQIGW NNTTDQRAFN EGMSDIWGVI MEHRIHPNSV
WQIGEQITRN YSCLRNLQNT NASNAMSQIA NTYASPQYNS GDSYVRGGVF SHWFYLLVNG
GTGVNTLGRN YSVWGIGMDN AENLIVKAVF GGYLRFTTSY AQIRTSMINA AREIAGTNSF
LEHQIENAWY AVGVGNTQYQ PHLSGPASVC DQATYTIENL PAGAIVQWSL SNNNAIILSS
TTDKVTLKRR NTGDVELRAN IRINSNPLNI NRNIWLFDPI LEASVYDNGI GWHNADMSYG
QIGLNLYQVT PNRDIHFRIN NAPLINIPIS NWEWVNYNPN IVSVSHQGGY IAHLTPLREG
RARINVRVKQ QGCYTNSIAL SIEVTSRSHF TLSPNPATDA VTLQLTETDE VNGLSVLSTD
RSPYEIQLWS GMTMLRSFRT NEPTFQISMA GLPAGLYFVR VVKDGQTYTQ KLIKK
//
