ID G8X446_STREN Unreviewed; 796 AA.
AC G8X446;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN OrderedLocusNames=SCATT_56700 {ECO:0000313|EMBL:AEW98041.1};
OS Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptantibioticus.
OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW98041.1, ECO:0000313|Proteomes:UP000007842};
RN [1] {ECO:0000313|Proteomes:UP000007842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC {ECO:0000313|Proteomes:UP000007842};
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC {ECO:0000256|ARBA:ARBA00005637}.
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DR EMBL; CP003219; AEW98041.1; -; Genomic_DNA.
DR AlphaFoldDB; G8X446; -.
DR STRING; 1003195.SCATT_56700; -.
DR KEGG; scy:SCATT_56700; -.
DR PATRIC; fig|1003195.29.peg.5652; -.
DR eggNOG; COG5520; Bacteria.
DR HOGENOM; CLU_015456_1_0_11; -.
DR Proteomes; UP000007842; Chromosome.
DR GO; GO:0004336; F:galactosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR049162; GH59_C.
DR InterPro; IPR049161; GH59_cat.
DR InterPro; IPR001286; Glyco_hydro_59.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR Pfam; PF02057; Glyco_hydro_59; 1.
DR Pfam; PF21708; Glyco_hydro_59_C; 1.
DR Pfam; PF14200; RicinB_lectin_2; 1.
DR PRINTS; PR00850; GLHYDRLASE59.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AEW98041.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Reference proteome {ECO:0000313|Proteomes:UP000007842};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..796
FT /note="galactosylceramidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003518594"
FT DOMAIN 656..793
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 796 AA; 82900 MW; B3A971E99447AF69 CRC64;
MALLLVAAAP LVAKPTAARA AIPTAITVDG DADGRVFDGV GAISGGGGNS RLLADYPEPQ
RSRILDYLFK PGYGAALQIL KVEIGGDTNS TDGAEPSHEH TRGAVDCDRG YEWWLMAQAK
ARNPGIKLYG LAWGAPGWIG GGHFWSQDMI DYLVSWLGCA KSHGLTVDYL GGWNERGYDK
AWYEKLHATM AADGYPTKVV GADSDWGVAD AMAADPAFAG SVDVVGAHYP CGYMSAMTSC
STTPAALASG KPLWASENGS EDFDTGGAPI ARALNRGYLD AKFTAFINWP LVAAVYQNLP
YNTMGLVTAS QPWSGAYRVG RSTWAVAHTT QFTRPGWSYV DPAGGYLGGS RANGSYVTYR
SPDRRAWSTV LETLDATAAQ PVTFKVTGGL PGGTLHVWSS DLSSPSQRDY LVHSADLTPG
GGVYALTLQP GHVYTVTTTT GQGAGTAVSP ARSRLALPYR DSFDTTPVGG EARYLADMNG
SFEAVPCGGG RHGTCVRQMA PTAPIAWDSP SDPYATAGDL SWSDYTVSVD TMLEQAGSAE
LLGRVGLQHG FDPADIDAYR LVLGADGGWS LLRGSASGTV TTLANGSVKA PGTGTWHTLA
LTFAGGSVTA AVDGVRLASV TDTAYGSGQV GIGTSGYVGA QFDNLGVTPG AAADLSGTYR
LVSRNSGQVL DAKGAGTADG TPVIQWPDNG GANQEWRLTA TGDGYYTLTG VGSGKALDVP
DHTTVAGTQL DLRTPDGTTA QQWLVVPARD GYYTVESRDT AELADVDGAA TTQGASVIQW
PADGGTNQQW QLVKVS
//
