ID G8XZP2_PICSO Unreviewed; 1245 AA.
AC G8XZP2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 22-FEB-2023, entry version 53.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=Piso0_005692 {ECO:0000313|EMBL:CCE87151.1};
GN ORFNames=GNLVRS01_PISO0N20495g {ECO:0000313|EMBL:CCE87151.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE87151.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FO082046; CCE87151.1; -; Genomic_DNA.
DR AlphaFoldDB; G8XZP2; -.
DR STRING; 559304.G8XZP2; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_0_1; -.
DR InParanoid; G8XZP2; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000005222; Chromosome N.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT DOMAIN 1071..1087
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 140337 MW; 132BFCA3B74886BA CRC64;
MKAEAKSKGA VLNNSSTSAV NARKKQMSLM SFFKPAKKEE IVTEQKTETF SKKTVNSGKA
EEDARSDSEK ENDTSIMDAP GDVPSPLTSE QDVSQGIAVK GTQLPNSSPV RKQEIEDREA
LHGIKRESVS EPADIASAEK RAGAESSKSR GLRTRKSQPV SYADSDSDQE GESVSGARKR
RRIVESDDDS DEFMPQDENA ESEDDMSDFV VDDEDVESQS EPEEESDYED IKKIKKSSGN
GKSARSSSSS TSPNVSEKPN SAKKTPNKDL AEKFTANSSY SVDSKPEVSR KPVPVATSKK
SFTKENEERY QWLVNIKDAQ KRPADDPEYD SRTLYIPQSA WSSFTAFEKQ YWEIKCKMWD
TVVFFKKGKF YELYENDAEI ANTEFDLKLA GGGRANMKLA GIPEMSFEYW AKEFIDHGYK
VAKVDQKETL LAKEMRGGST KEEKIIKREL TGILTGGTLT DLNMINDDMS VYCLSIREEI
LDNGCKLFGI AFVDTATSEM NLVEFEDDQE CTKLDTLITQ VKPKEIICEK NNLCSIATKI
LKFSSHSTNQ IWNNLNPISE FWDYDTTLEK LIKGSYYEAE DLDDFSHYPS TLVQYKDEKK
CAFHAFGGLL FYLRSLKLDS SILSLGNIKE YIISKNTATH LILDGVSLSN LEVLNNSFDG
TDKGTLFKLI NRAITPFGKR MLKTWLLHPL MDIKKINERY DSIDFFMNGG IEFKEMLEKT
LNSLPDLERL LARIHGKTLK FKDFLRVVES YESIAKLTSS IKDYDFTNTG ALYSYISNIP
KELETCISHW EDAFDRTEAL SDNIVPMKGV DSEFDNSSEA LASLEAQLEE HLRTYRKEFK
SNEICYKDSG KEVYLIEVPN KIKNIPHDWQ QMGSTSKVKR YWSPEVRKLV RELLEQRELH
KMVCETLKFR MYEKFEKDYS TYMRTLQILA KIDCLIALTK TSETIGFPSC RPAFIESNKG
QVEFKELRHP CFTGTKDFIP NDVVLGGSKP NMGLLTGANA AGKSTIMRTT ALAIILSQIG
CYVPASFAAL TPVDRIMTRL GANDNIMQGK STFFVELSET KRILSRTTPK SFVILDELGR
GGSSSDGFSI AEAVLHHIAT HIQSLGFFAT HFGSLGLSFR NHPQIRPMRM GILVDENTRN
ITFLYKLEEG TAPGSFGMNV AAMCGIAEEI VSNAERAAEE YEKQSRIKRH STLQAQNSNE
LSLGLQSDFV WFACEEKDMS KDVFLYDKAT KEGALQNVFS MIDKL
//
