ID   G8YH40_PICSO            Unreviewed;       311 AA.
AC   G8YH40;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
GN   Name=Piso0_003070 {ECO:0000313|EMBL:CCE80742.1};
GN   ORFNames=GNLVRS01_PISO0G04230g {ECO:0000313|EMBL:CCE79977.1},
GN   GNLVRS01_PISO0H04231g {ECO:0000313|EMBL:CCE80742.1};
OS   Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS   10061 / NRRL Y-12695) (Hybrid yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX   NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE80742.1, ECO:0000313|Proteomes:UP000005222};
RN   [1] {ECO:0000313|EMBL:CCE80742.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Genoscope - CEA;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000005222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC   Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX   DOI=10.1534/g3.111.000745;
RA   Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA   Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA   Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA   Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA   Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA   Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA   Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA   Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT   "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT   genome resolution following polyploidization.";
RL   G3 (Bethesda) 2:299-311(2012).
CC   -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC       (EMC) that enables the energy-independent insertion into endoplasmic
CC       reticulum membranes of newly synthesized membrane proteins.
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SIMILARITY: Belongs to the EMC2 family.
CC       {ECO:0000256|RuleBase:RU367091}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO082053; CCE79977.1; -; Genomic_DNA.
DR   EMBL; FO082052; CCE80742.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8YH40; -.
DR   STRING; 559304.G8YH40; -.
DR   eggNOG; KOG3060; Eukaryota.
DR   HOGENOM; CLU_065213_0_0_1; -.
DR   InParanoid; G8YH40; -.
DR   Proteomes; UP000005222; Chromosome G.
DR   Proteomes; UP000005222; Chromosome H.
DR   GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR039856; EMC2-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW   Membrane {ECO:0000256|RuleBase:RU367091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          155..188
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   311 AA;  35812 MW;  F973782010C3A0E2 CRC64;
     MAHEISTEAL KDKLLNISYS GVYAQFHPEQ LLDLYNEVSN FLSINSDSID VTELFNLTEL
     RFYLAILTHH DVDSKACLDR LTDQFGRDRS QRIKILQSIY LEAMGDNEGA KLLLNGDPDE
     LDLSRRLVTF SRNSSDPEEY IACLKFYLDV QPSDLITWAE LADQYQQLGH YERAIFCLQE
     IIQQEPFAYN IFYKIGLNYY YLYCREFSPK LEKKDKVLES ANILRKARDH FLRTIEICET
     YSKAWLGIYL VTKAPINDVL RAKYKDNSAM GQLLSENDKL REVSAKKFTD LSGIDEATLK
     SDLSVSATPS A
//