ID G8YQX4_PICSO Unreviewed; 1382 AA.
AC G8YQX4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Cation-transporting ATPase {ECO:0000256|RuleBase:RU362082};
DE EC=7.2.2.- {ECO:0000256|RuleBase:RU362082};
GN Name=Piso0_001096 {ECO:0000313|EMBL:CCE79059.1};
GN ORFNames=GNLVRS01_PISO0C10804g {ECO:0000313|EMBL:CCE78473.1},
GN GNLVRS01_PISO0D10871g {ECO:0000313|EMBL:CCE79059.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE79059.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|EMBL:CCE79059.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|RuleBase:RU362082};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362082}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362082}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000,
CC ECO:0000256|RuleBase:RU362082}.
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DR EMBL; FO082057; CCE78473.1; -; Genomic_DNA.
DR EMBL; FO082056; CCE79059.1; -; Genomic_DNA.
DR STRING; 559304.G8YQX4; -.
DR eggNOG; KOG0208; Eukaryota.
DR HOGENOM; CLU_001828_1_1_1; -.
DR InParanoid; G8YQX4; -.
DR OMA; FSCFQYM; -.
DR Proteomes; UP000005222; Chromosome C.
DR Proteomes; UP000005222; Chromosome D.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:InterPro.
DR CDD; cd07542; P-type_ATPase_cation; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047819; P5A-ATPase_N.
DR InterPro; IPR047821; P5B-type_ATPase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630:SF8; CATION-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01229; COF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362082};
KW Magnesium {ECO:0000256|RuleBase:RU362082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362082};
KW Metal-binding {ECO:0000256|RuleBase:RU362082};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362082};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362082}.
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 432..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 633..657
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 669..690
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1141..1159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1171..1188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1209..1231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1251..1273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1285..1303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1323..1341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT DOMAIN 252..378
FT /note="P5B-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12409"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1382 AA; 157209 MW; C2039DBD54A9A557 CRC64;
MTHDNSRGNS FKSKRPSMVG RRSRQNSVLS VESSVSHLVD ENTQEMYSGA ASEIIPSSIS
SFHYPHNFRS KRAGSSVNTL SNEASPLLQT TDHTLENFDL HSVHSGSSHK SNDNALGFRF
FLPQEIEGAP GGSTLENPED PVDYNTKWDY SVDKYDDEEI DPLSREGTSA LFRRGSRETS
EGYDNESAFT EGEGGIGSRS SSESHFERRM RRDSEDSDKN DSSIEELLDD TVKEDLNFPA
SSEYQRFYLA EEDLVIGVAG YKDNDLKKAL YYFFCILTLG MGYLVLRWLP KYRVSFMGDK
TPLGKADWCV IENEYGELTI VPITKEKYDG RLSSFLNVQT EDSSKSSYSK QNYQERENDP
FVTRIHSFTY RYLKFFYSPV EDIFKTNGNW YDIHWLNLKN TKDGISETTH KSRSQIFGKN
DIIIDEKSVP QLLVDEVLHP FYIFQVFSIF LWLADNYYYY ATCIFLISLL SIVNSLVETK
STLKRLKEMS VFSCEVRVWR NDFWTQINSC DLVPGDVFEV DPTLTVLPCD ALLVNGECIV
NESMLTGESV PVSKISASPE TLQCLLDDFT TPKLAKSYLY NGTKLLKMKT SNDEPVTATV
LKTGFNTTKG SLVRSMLFPK PTGFKFYQDS FKYIGFMTMI AFIGFTYSTY NFIQLGLPKR
LMLLRALDII TIVVPPALPA TLTIGTTFAV NRLRKKNIFC IAPTRVNIGG KLDVVCFDKT
GTLTEDGLDV LGIHVAENAA GRKEIVFKDI IDDIGFLESG FRGKDHYSTN NSKYLLGAMA
ACHSLRLVDN ELIGDPLDAK MFQFTKWNFM EEYDGPHSLV YPVYESEGYI IVREFEFISY
LRRMSVVVRD RNDDTFIFTK GAPEVMSDIC IPETLPENYE DILHRYTHQG FRVIALAYKE
LRDVKELSSL SREETENGLS FAGFIVFENK LKESTKPTLQ KLNEANIRTV MCTGDNILTA
VSVSRECELL EKSVQNVYFP VYQEGANETN LVWEDLNDSE NKLDPILLKP LNSNIRNEVT
QQNSEYYRLA ITGDIFRYLL TEVKNVSLIQ RVLMKCDIYA RMSPDEKHEL VEQLQKLDYT
VGFCGDGAND CGALKAADVG VSLSEAEASV AAPFTSRVFE ITCILDVIKE GRSSLVTSFS
CFKYMSLYSA IQFVTVSIMY KRGINLGDFQ FLYIDLFLIL PLAIFMSWSK PYDTIVVKRP
PANLVSIKVL IPMCCHILTL LVFQVALWLL VQQQPWYIKP VPGDDDDVQS FDNTILFLFS
NFQYIFIAIV LSVGPPYREP VMKNVPFLVN VVVSTCISLA LFWVDGDSRW GTFMQLTNLP
TSFYYIIILA ALANLALMYA GEDSWFVRLA KTAKRCYLRG KPRKSKKLFK NLRKEYVSLQ
EV
//
