ID G8YUE6_PICSO Unreviewed; 2471 AA.
AC G8YUE6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 28-JUN-2023, entry version 44.
DE SubName: Full=Piso0_000055 protein {ECO:0000313|EMBL:CCE72479.1};
GN Name=Piso0_000055 {ECO:0000313|EMBL:CCE72479.1};
GN ORFNames=GNLVRS01_PISO0A01056g {ECO:0000313|EMBL:CCE72479.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE72479.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
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DR EMBL; FO082059; CCE72479.1; -; Genomic_DNA.
DR STRING; 559304.G8YUE6; -.
DR eggNOG; KOG1795; Eukaryota.
DR HOGENOM; CLU_000380_3_0_1; -.
DR InParanoid; G8YUE6; -.
DR OMA; ANKWNTS; -.
DR Proteomes; UP000005222; Chromosome A.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2234..2369
FT /note="JAB1/MPN/MOV34 metalloenzyme"
FT /evidence="ECO:0000259|SMART:SM00232"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..74
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2471 AA; 285067 MW; 86A7D5A6500B1A3F CRC64;
MQRGDPPQKV DEDIGSARGK SLASQSENKG KQRRNDIPPP PPPPTASAGK ARHPDNKNGS
KLPPPPPPPP SAPSSKMGSR GNSSSNGARG IQKRRRTDND GHTANASGGL PPPPPPPPPP
GKVDSVSDLR QDVADSSKLS IKELKERKNN WMRSQRDKFK VVTVKQSKQK GIVQPRKIEM
PPEHLRKIMF DHGDMSSKKF ASEKRSHLGA LKYLPHAILK LLENMPQPWE NAKEVKVLYH
ITGAITFVNE IPRVIEPVYT AQWASAWIQM RREKRDRKHF KRIRFPPFDD EEPPLDWMEN
IEELELPEPL TLELDSFKDN EVMEWLYDEK PLIEDSKVVN GDSYRRWNLN LNRMAALYKL
SQPLLPDVID PNYFYLFDKD AFFTSKSLNA VLPGGPRFEP LFKDKINNSE LEDYTEFNSI
DRIIFRIPIK VEYKIAFPFL YNSFVKQVYP GWYHEPLNCS SYSMNNSEAF TFNPNFNLIP
PRRRKAIKAY RSKGEDVNDE LPLKGNLRPL METEDGELLD IAPEGTSSAI DLWWAPYPFN
RRSGKMKRAH DVALTKSWYQ QHPHTDEKLK VRISHQKLLK KYVLNELHNP PRSQKRNHMG
YQKKVKLLKS LRSTKYFQET TIDWVEAGLQ VCRQGFNMLN LLIHKRGLTY LHLDYNFNLK
PTKTLTTKER KKSRFGNAFH LIREIMRVVK ILVDSHVQYR LGNIDAFQLA DGIHYIFNHL
GQLTGIYRYK YKVMHQIRAC KDLKHLIYSR FNAIIGKGPG CGFWQPAWRV WIFFMRGIIP
LLERWLGNLL SRQFEGRRSN DVAKTVTKQR VDSYYDIELR AQVMHDILDM IPEGLKQNKS
KAILQHLSEA WRCWKANIPW KVPGMPAPIE QIIVRYIKAK ADGWISMAHY NRERIRKGAT
VEKTVAKKNL GRLTRLWIKN EQERQLSFAK DGPYVTPDQA VSIFQTAVYW FESRKFSPIP
FPPLSYKHDN KLLVLALENL KESYNANARL NSSQREELAL IEQAYDNPHE CLARIKKFLL
TQRIFKEVGL EMMDYYTHII PTYSIDPLEK ITDAYLDQYL WYEADKRHLF PNWVKPSDDE
IPPLLVYKWC QGVNNLENVW DTSNGECNAI LQSSLHKVFE NIDLTLLNRL LRLIMDPNLA
DYITSKNNVS ITYKDMNHIN QYGLIRGLQF SSFVFQYYGL VIDLLILGLD RASEIAGIPQ
LPNQFLQFKD GSETSSPIRL YARYMDKIFM FFRLDSEETD GLISDFLSEN PDPNFENIVG
YNNHRCWPRD ARMKLVRHDV NLGRALHWEI AGRIPKSLTS ILWEDTIVSV YSRDNPNLLF
SMCGFEVRIL PKVRAKESLS SEEGTWDLID QKTKERTAKA FLKVSDEEVD NFNSRIRQIL
MSSGSTTFTK VAAKWNTALI ALLAYFREAV ISTESLLDVL VRCETKIQNR VKMGLNSKMP
SRFPPAVFYT PKELGGLGML SASNILIPAS DLRWSKQTDT GITHFRAGMT HDDNKIIPTI
FRYITSWENE FLDSQRVWAE YAIKRQEALE QNRRITFEDM ENNWERGIPR ISTLFQKDRH
TLAYDKGHRA RKAFKRYSIA RFNPFSWTNN HHDGKLWNLN AYRTDVIQAL GGIETILEHT
LFKGTGFDSW EGLFWEKASG FEDSLKFKKL TNAQRSGLSQ IPNRRFTLWW SPTINRANVY
VGFLVQLDLT GIFLHGKIPT LKISLIQIFR AHLWQKIHES VVQDICQVLD KEIDVLQVDS
VEKQAIHPRK SYKMNSSCAD IVLTSNYKWN TSRPSLLFDK HDDLNFATAS KYWIDVQLRY
GDYDSHDISR YVRAKFLDYT TDSTSSYPSP TGAMVGIDLA YNMYDVYGNW FSGLKPLMQS
AMKEIMKSNP ALYVLRERIR KALQLYQAQP QEALLNSSNY AELFNNETQF FIDDTNVYRV
TVHKTFEGNL TTKPINGAAF IMNPKSGQLF LKIIHTSVWA GQKRLGQLAK WKTAEEVAAL
VRSLPREEQP KQLIVTRKGM LDPLEVHMLD FPNMSIRQSE LHLPFASALK VDKLADVVLK
ANEPQMVLFN LYDDWLRSIS SYTAFSRLVL ILRALGINQE RTNLILRPDA SVVTQAHHIW
PTFTDEQWID VETQLRDLIL NDYAKKHNIN IQALTQSEIR DLILGQEIKA PSVKRQEISE
LENGSNEGEQ NEQLTALKST TQNVHGEDIV TVTTTNYEQQ TFSSKHEWRN RAIAANNLHL
RTRNIYVSTD DYQEDGITYI IPQNLLKKFI QISDVRTQVA AYLYGSSPED NAQVKEIKYI
ALVPQLGNLN SVQLPLNLPE LEGPLSELEL IGLIHTQAQD IKALTAPEVT ALARLKDKNS
KKWPENFITI KAALTPGSIT LSSYFLSEEG YEWGSQNSDL ISQQPKGYST SFSVKGQILL
SDRLSGSTLV PEDDIWNYTF MGALWDSEIP IKLKVDIPLA FYNDLHRPVH FSNFNDIEGS
NLEADQEDNL S
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