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Database: UniProt
Entry: G8ZN00_TORDC
LinkDB: G8ZN00_TORDC
Original site: G8ZN00_TORDC 
ID   G8ZN00_TORDC            Unreviewed;       822 AA.
AC   G8ZN00;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TDEL0A06620 {ECO:0000313|EMBL:CCE89994.1};
GN   ORFNames=TDEL_0A06620 {ECO:0000313|EMBL:CCE89994.1};
OS   Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 /
OS   NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Torulaspora.
OX   NCBI_TaxID=1076872 {ECO:0000313|Proteomes:UP000005627};
RN   [1] {ECO:0000313|EMBL:CCE89994.1, ECO:0000313|Proteomes:UP000005627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866
RC   {ECO:0000313|Proteomes:UP000005627};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE616742; CCE89994.1; -; Genomic_DNA.
DR   RefSeq; XP_003679205.1; XM_003679157.1.
DR   STRING; 4950.XP_003679205.1; -.
DR   EnsemblFungi; CCE89994; CCE89994; TDEL_0A06620.
DR   GeneID; 11502534; -.
DR   KEGG; tdl:TDEL_0A06620; -.
DR   InParanoid; G8ZN00; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000005627; Chromosome 1.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:EnsemblFungi.
DR   GO; GO:0016049; P:cell growth; IEA:EnsemblFungi.
DR   GO; GO:0043623; P:cellular protein complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005627};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005627};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    411    435       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    455    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    533    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    627    645       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    722    745       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    751    774       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      111    141       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   822 AA;  93223 MW;  7B1146106E3CF201 CRC64;
     MQEKQEAIFR SADMSLVQLY IPQEIARETV YTLGQLGLVQ LRDMNTKVRA FQRAFVDDIR
     KLDNVERQYR YFYKLLNKHK INLLEVELPE ENGLVELAPG TGKIDDHVQN ASYLEDRLVQ
     MEEASEQLEL QKTDLEQYRF LLKSGDQFFS KDIQAGVGAA PDNDDEEMNV GAALPSSVNY
     VTGVISRQKV GILEQILWRV LRGNLYFRHV ELAEPVYDAK TKGKVLKNAF IVFSHGDLIL
     KRIQKIAESL DATLYDVESS AEARSAQLSQ TNQSLGDLNT VLETTSTTLD SELYAIAKEL
     DSWYQDISRE KSVYETLNKF NFDVNRKTLI AEGWVPRDQL LILQDKLGQM TAKLGNDVPS
     IIQVLETNKT PPTFHRTNKF TAGFQSICDC YGIAQYQEIN PGLPTIVTFP FMFAIMFGDL
     GHGTLMAMVA LVLVLNEKKI DRMKRGEIFD MLYGGRYIVL FMGLFSMYTG FLYNDIFSKS
     MTLFKSGWKW PEHWEIGEAI TAHQVGTYPI GLDWAWHGTD NALLFANSYK MKLSVLMGFI
     HMTYSYFFSL ANHIFFNSWI DIVGNFIPGL LFMQGIFGYL SVCIVYKWAV DWVKDGKPAP
     GLLNMLINMF LAPGKIDDEL YPHQAKVQVI LLLVALLCIP CLLIIKPLHF KLTHKDHELV
     ATEDELEVEQ LLGNDELADS DEEEGEEHAH DEQFSDVMIH QVIHTIEFCL NCVSHTASYL
     RLWALSLAHA QLSSVLWTMT IQIAFGFTGA VGVFATVFLF AMWFALTCAV LVGMEGTSAM
     LHSLRLHWVE SMSKFFVGEG LPYEPFIFQY AELGAEAPAG PV
//
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