ID G9BFS6_PIG Unreviewed; 147 AA.
AC G9BFS6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Insulin-like growth factor I {ECO:0000256|ARBA:ARBA00018817};
DE AltName: Full=Somatomedin {ECO:0000256|ARBA:ARBA00030022};
GN Name=IGF1 {ECO:0000313|EMBL:AER08607.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AER08607.1};
RN [1] {ECO:0000313|EMBL:AER08607.1}
RP NUCLEOTIDE SEQUENCE.
RA Duan Q., Li J., Wang Y.;
RT "Pig Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2) Genes: Isoform
RT Identification, Functional Characterization, and Promoter Analysis.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC01910.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
CC -!- SUBUNIT: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a
CC ternary complex with IGFR1 and ITGA6:ITGB4.
CC {ECO:0000256|ARBA:ARBA00011603}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HQ450748; AER08607.1; -; mRNA.
DR EMBL; DQIR01246432; HDC01910.1; -; Transcribed_RNA.
DR SMR; G9BFS6; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0010648; P:negative regulation of cell communication; IEA:UniProt.
DR GO; GO:0023057; P:negative regulation of signaling; IEA:UniProt.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR PANTHER; PTHR46845:SF1; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..48
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 49..147
FT /note="Insulin-like growth factor I"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040662652"
FT DOMAIN 51..109
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT DISULFID 54..96
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 66..109
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 95..100
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 147 AA; 16314 MW; C675C82AB21E29BC CRC64;
MGKISSLPTQ LFKCCFCDFL KVKMHITSSS HLFYLALCLL SFTSSATAGP ETLCGAELVD
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
VRAQRHTDMP KAQKVYMQTG QSRGNNQ
//
