ID G9BLN9_9PLVG Unreviewed; 338 AA.
AC G9BLN9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AEC50329.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AEC50329.1};
OS Human immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Primate lentivirus group.
OX NCBI_TaxID=12721 {ECO:0000313|EMBL:AEC50329.1};
RN [1] {ECO:0000313|EMBL:AEC50329.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM111360 {ECO:0000313|EMBL:AEC50329.1};
RA Goldsamt L., Clatts M., Parker M., Colon V., Hallack R., Messina M.;
RT "Prevalence of sexually-acquired antiretroviral drug resistance in a
RT community sample of HIV-positive MSM in New York City.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; HQ610132; AEC50329.1; -; Genomic_RNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 19..88
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 142..332
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT UNSURE 63
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AEC50329.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEC50329.1"
FT NON_TER 338
FT /evidence="ECO:0000313|EMBL:AEC50329.1"
SQ SEQUENCE 338 AA; 38613 MW; DFFF282420CF6C7D CRC64;
QITLWQRPLV TIKIGGQLKE ALLDTGADDT VLEEMDLPGR WKPKMIGGIG GFIKVXQYXZ
IXXEICGHKA IGTVLVGPTP VNIIGRNLLT QIGCTLNFPI SPIETVPVKL KPGMDGPRVK
QWPLTEEKIK ALXEICTDME KEGKISKIGP ENPYNTPVFA IKKKDSTKWR KLVDFRELNK
RTQDFWEVQL GIPHPAGLKK KKSVTVLDVG DAYFSVPLDX EFRKYTAFTI PSINNETPGI
RYQYNVLPQG WKGSPAIFQS SMTKILEPFR KQNPXXVIYQ YMDDLYVGSD LEIGQHRTKI
EELRQHLLRW GFTTPDKKHQ KEPPFLWMGY ELHPDKWT
//
