ID   G9CHV1_9NEOB            Unreviewed;       218 AA.
AC   G9CHV1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Chemokine receptor 4 {ECO:0000313|EMBL:AEU04110.1};
DE   Flags: Fragment;
GN   Name=CXCR4 {ECO:0000313|EMBL:AEU04110.1};
OS   Peltophryne gundlachi (Cuban high-crested toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Peltophryne.
OX   NCBI_TaxID=156876 {ECO:0000313|EMBL:AEU04110.1};
RN   [1] {ECO:0000313|EMBL:AEU04110.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bg002 {ECO:0000313|EMBL:AEU04110.1};
RA   Alonso R., Crawford A.J., Bermingham E.;
RT   "Molecular phylogeny of an endemic radiation of Cuban toads (Bufonidae:
RT   Peltophryne) based on mitochondrial and nuclear genes.";
RL   J. Biogeogr. 39:434-451(2012).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; JF342423; AEU04110.1; -; Genomic_DNA.
DR   AlphaFoldDB; G9CHV1; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001277; CXCR4/ACKR2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00645; CXCCHMKINER4.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AEU04110.1};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..218
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEU04110.1"
FT   NON_TER         218
FT                   /evidence="ECO:0000313|EMBL:AEU04110.1"
SQ   SEQUENCE   218 AA;  24778 MW;  C1867C42A4E4B849 CRC64;
     FVFTLPFWSV DAAIGWYFKE FLCKAVHVIY TVNLYSSVLI LAFISLDRYL AIVHATNSQG
     SRKLLAEKIV YAGVWLPAIL LTVPDVVFAS VSDIDGNFVC DRIYPVENRE HWTIGFRFLH
     ITVGLVLPGL IILTCYCVII SKLSHSKGHQ KRKALKTTVI LILAFFACWL PYYICLTIDT
     FGLLRLLKFD CYMDSTLHKS ISITEALAFF HCCLNPIL
//